Evidence of Lateral Transmission of Aggressive Features Between Different Types of Breast Cancer Cells

Overview

Journal Int J Oncol

Specialty Oncology

Date 2017 Oct 20

PMID 29048610

Citations 16

Authors

Nancy Adriana Espinoza-Sanchez

Eduardo Vadillo

Juan Carlos Balandran

Alberto Monroy-Garcia

Rosana Pelayo

Ezequiel M Fuentes-Panana

Affiliations

Soon will be listed here.

Abstract

Breast cancer (BrC) is a major public health problem worldwide. The intra-tumoral heterogeneity and tumor cell plasticity importantly contribute to disease progression and treatment failure. However, the dynamic interactions between different tumor clones, as well as their contribution to tumor aggressiveness are still poorly understood. In this study, we provide evidence of a lateral transmission of aggressive features between aggressive and non-aggressive tumor cells, consisting of gain of expression of cancer stem cell markers, increased expression of CXCL12 receptors CXCR4 and CXCR7 and increased invasiveness in response to CXCL12, which correlated with high levels of secretion of pro-inflammatory mediators G-CSF, GM-CSF, MCP-1, IL-8 and metalloproteinases 1 and 2 by the aggressive cells. Noteworthy, we found no evidence of a TGF-β participation in the inducible-invasive phenotype. Altogether, our results provide evidence of communication between tumor cells with different potentials for aggressiveness, which could influence intra-tumoral population dynamics promoting the emergence of clones with novel functions. Understanding these interactions will provide better targets for diagnosis, prognosis and therapeutic strategies.

Citing Articles

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Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis.

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Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones.

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Pacheco-Velazquez S, Ortega-Mejia I, Vargas-Navarro J, Padilla-Flores J, Robledo-Cadena D, Tapia-Martinez G Front Oncol. 2022; 12:1018137.

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Cancer Biology, Epidemiology, and Treatment in the 21st Century: Current Status and Future Challenges From a Biomedical Perspective.

Pina-Sanchez P, Chavez-Gonzalez A, Ruiz-Tachiquin M, Vadillo E, Monroy-Garcia A, Montesinos J Cancer Control. 2021; 28:10732748211038735.

PMID: 34565215 PMC: 8481752. DOI: 10.1177/10732748211038735.

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