Amlexanox, a Selective Inhibitor of IKBKE, Generates Anti-tumoral Effects by Disrupting the Hippo Pathway in Human Glioblastoma Cell Lines

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2017 Oct 20

PMID 29048430

Citations 26

Authors

Yang Liu

Jie Lu

Zhimeng Zhang

Lin Zhu

Shicai Dong

Gaochao Guo

Ruohong Li

Yang Nan

Kai Yu

Yue Zhong

Qiang Huang

Affiliations

Soon will be listed here.

Abstract

Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proliferation and invasion and induced apoptosis in glioblastoma cells. Furthermore, we found that amlexanox altered the protein expression of the Hippo pathway by downregulating IKBKE. Our data indicates that IKBKE directly targets LATS1/2 and induces degradation of LATS1/2, thereby inhibiting the activity of the Hippo pathway. In vivo results further confirmed the tumor inhibitory effect of amlexanox via the downregulation of IKBKE, and amlexanox induced no apparent toxicity. Collectively, our studies suggest that amlexanox is a promising therapeutic agent for the treatment of GBM.

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