Aortic Stiffness in Aging and Hypertension: Prevention and Treatment with Habitual Aerobic Exercise

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2017 Oct 20

PMID 29046980

Citations 19

Authors

Gary L Pierce

Affiliations

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Abstract

Purpose Of Review: Habitual aerobic exercise is associated with lower aortic stiffness, as measured by carotid-femoral pulse wave velocity (CFPWV), in middle-aged/older adults without hypertension, but beneficial effects of aerobic exercise on CFPWV in hypertension remain contraversial. Therefore, the focus of this review is to discuss the evidence for and against the beneficial effects of aerobic exercise on aortic stiffness in middle-aged and older adults with hypertension, possible limitations in these studies, and highlight novel directions for future research.

Recent Findings: Most randomized controlled intervention studies demonstrate that short-term aerobic exercise results in no reductions in CFPWV in middle-aged and/or older adults with treated or treatment-naïve hypertension. Higher aerobic fitness is not associated with lower aortic stiffness among older adults with treated hypertension. Aortic stiffness appears to be resistant to clinically relevant improvements in response to habitual aerobic exercise in the presence of hypertension among middle-aged and older adults.

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References

Mitchell G, Parise H, Benjamin E, Larson M, Keyes M, Vita J . Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004; 43(6):1239-45. DOI: 10.1161/01.HYP.0000128420.01881.aa. View

Pierce G, Harris S, Seals D, Casey D, Barlow P, Stauss H . Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. J Hum Hypertens. 2016; 30(9):513-20. PMC: 4981524. DOI: 10.1038/jhh.2016.3. View

Scuteri A, Morrell C, Orru M, Strait J, Tarasov K, Ferreli L . Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging. Hypertension. 2014; 64(6):1219-27. PMC: 4231012. DOI: 10.1161/HYPERTENSIONAHA.114.04127. View

Stewart K, Bacher A, Turner K, Fleg J, Hees P, Shapiro E . Effect of exercise on blood pressure in older persons: a randomized controlled trial. Arch Intern Med. 2005; 165(7):756-62. DOI: 10.1001/archinte.165.7.756. View

Alghatrif M, Lakatta E . The conundrum of arterial stiffness, elevated blood pressure, and aging. Curr Hypertens Rep. 2015; 17(2):12. PMC: 4524667. DOI: 10.1007/s11906-014-0523-z. View

Mceniery C, Yasmin , Hall I, Qasem A, Wilkinson I, Cockcroft J . Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005; 46(9):1753-60. DOI: 10.1016/j.jacc.2005.07.037. View

Gates P, Tanaka H, Graves J, Seals D . Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. Eur Heart J. 2003; 24(24):2213-20. DOI: 10.1016/j.ehj.2003.09.026. View

Avolio A, Chen S, Wang R, Zhang C, Li M, ORourke M . Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation. 1983; 68(1):50-8. DOI: 10.1161/01.cir.68.1.50. View

Maeda S, Otsuki T, Iemitsu M, Kamioka M, Sugawara J, Kuno S . Effects of leg resistance training on arterial function in older men. Br J Sports Med. 2006; 40(10):867-9. PMC: 2465061. DOI: 10.1136/bjsm.2006.029538. View

10.

Donley D, Fournier S, Reger B, DeVallance E, Bonner D, Olfert I . Aerobic exercise training reduces arterial stiffness in metabolic syndrome. J Appl Physiol (1985). 2014; 116(11):1396-404. PMC: 4044399. DOI: 10.1152/japplphysiol.00151.2014. View

11.

Mitchell G, Hwang S, Vasan R, Larson M, Pencina M, Hamburg N . Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010; 121(4):505-11. PMC: 2836717. DOI: 10.1161/CIRCULATIONAHA.109.886655. View

12.

Pierce G, Casey D, Fiedorowicz J, Seals D, Curry T, Barnes J . Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences. Am J Physiol Heart Circ Physiol. 2013; 305(1):H135-42. PMC: 3727109. DOI: 10.1152/ajpheart.00916.2012. View

13.

Mceniery C, Yasmin , Maki-Petaja K, McDonnell B, Munnery M, Hickson S . The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III). Hypertension. 2010; 56(4):591-7. DOI: 10.1161/HYPERTENSIONAHA.110.156950. View

14.

Cortez-Cooper M, DeVan A, Anton M, Farrar R, Beckwith K, Todd J . Effects of high intensity resistance training on arterial stiffness and wave reflection in women. Am J Hypertens. 2005; 18(7):930-4. DOI: 10.1016/j.amjhyper.2005.01.008. View

15.

Seals D, Tanaka H, Clevenger C, Monahan K, Reiling M, Hiatt W . Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: role of arterial stiffness. J Am Coll Cardiol. 2001; 38(2):506-13. DOI: 10.1016/s0735-1097(01)01348-1. View

16.

Moreau K, Gavin K, Plum A, Seals D . Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women. Menopause. 2006; 13(6):951-8. DOI: 10.1097/01.gme.0000243575.09065.48. View

17.

Dinenno F, Tanaka H, Monahan K, Clevenger C, Eskurza I, DeSouza C . Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol. 2001; 534(Pt 1):287-95. PMC: 2278690. DOI: 10.1111/j.1469-7793.2001.00287.x. View

18.

Laurent S, Katsahian S, Fassot C, Tropeano A, Gautier I, Laloux B . Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003; 34(5):1203-6. DOI: 10.1161/01.STR.0000065428.03209.64. View

19.

Blacher J, Guerin A, Pannier B, Marchais S, Safar M, London G . Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999; 99(18):2434-9. DOI: 10.1161/01.cir.99.18.2434. View

20.

Mattace-Raso F, van der Cammen T, Hofman A, van Popele N, Bos M, Schalekamp M . Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006; 113(5):657-63. DOI: 10.1161/CIRCULATIONAHA.105.555235. View