[Spondyloarthritides]

Overview

Journal Z Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2017 Oct 19

PMID 29043434

Citations 2

Authors

M Rudwaleit

Affiliations

Soon will be listed here.

Abstract

Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets. Inflammatory back pain is the leading symptom in axial SpA and has certain characteristics. In addition, HLA-B27 and sacroiliitis on imaging are important for diagnosis. Therapy consists of physiotherapy, nonsteroidal anti-inflammatory drugs (first line) and biologicals (second line). Conventional disease-modifying antirheumatic drugs are effective only in peripheral arthritis.

Citing Articles

Spondyloarthritis and Strength Training: A 4-Year Report.

Cannataro R, Di Maio L, Malorgio A, Levi Micheli M, Cione E J Funct Morphol Kinesiol. 2021; 6(3).

PMID: 34202441 PMC: 8293414. DOI: 10.3390/jfmk6030058.

Tubulointerstitial Nephritis Associated with Enteritis and Sacroiliitis.

Ushimaru S, Ichikawa D, Yazawa M, Suzuki T, Okada E, Koike J Intern Med. 2018; 58(1):79-84.

PMID: 30146576 PMC: 6367097. DOI: 10.2169/internalmedicine.1255-18.

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