The Combined Strategy of Mesenchymal Stem Cells and Tissue-engineered Scaffolds for Spinal Cord Injury Regeneration

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2017 Oct 19

PMID 29042919

Citations 17

Authors

Rosaliana Libro

Placido Bramanti

Emanuela Mazzon

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) is a traumatic lesion that can result in the loss of motor or sensory neurons. Stem cell (SC)-based therapies have been demonstrated to promote neuronal regeneration following SCI, by releasing a range of trophic factors that support endogenous repair or by differentiating into neurons, or glial cells in order to replace the damaged cells. However, numerous limitations remain for therapies based on SC transplantion alone, including a low rate of survival/engraftment. Nevertheless, scaffolds are 3-dimentional substrates that have revealed to support cell survival, proliferation and differentiation , by mimicking a more favorable endogenous microenvironment. A multidisciplinary approach, which combines engineered scaffolds with SCs has been proposed as a promising strategy for encouraging spinal cord regeneration. The present review has focused on the regenerative potential of mesenchymal SCs isolated from different sources and combined with various scaffold types, in preclinical and clinical SCI studies.

Citing Articles

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis.

Wang Z, Li J, Xu T, Guo B, Xie Z, Li M Cell Mol Neurobiol. 2024; 44(1):43.

PMID: 38703332 PMC: 11069479. DOI: 10.1007/s10571-024-01465-6.

Combinatorial strategies for cell transplantation in traumatic spinal cord injury.

Jagrit V, Koffler J, Dulin J Front Neurosci. 2024; 18:1349446.

PMID: 38510468 PMC: 10951004. DOI: 10.3389/fnins.2024.1349446.

Open-Spaced Ridged Hydrogel Scaffolds Containing TiO-Self-Assembled Monolayer of Phosphonates Promote Regeneration and Recovery Following Spinal Cord Injury.

Siddiqui A, Thiele F, Stewart R, Rangnick S, Weiss G, Chen B Int J Mol Sci. 2023; 24(12).

PMID: 37373396 PMC: 10299197. DOI: 10.3390/ijms241210250.

The Metabolic Changes between Monolayer (2D) and Three-Dimensional (3D) Culture Conditions in Human Mesenchymal Stem/Stromal Cells Derived from Adipose Tissue.

Rybkowska P, Radoszkiewicz K, Kawalec M, Dymkowska D, Zablocka B, Zablocki K Cells. 2023; 12(1).

PMID: 36611971 PMC: 9818744. DOI: 10.3390/cells12010178.

Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review.

Bonosi L, Poullay Silven M, Alessandro Biancardino A, Sciortino A, Giammalva G, Scerrati A Int J Mol Sci. 2022; 23(21).

PMID: 36361786 PMC: 9657320. DOI: 10.3390/ijms232112996.

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