Objective:
Although cognitive stimulation (CS) is one of the most popular non-pharmacological interventions for people with dementia, its efficacy is still debatable. We performed a meta-analysis of randomized controlled trials (RCTs) on the efficacy of CS in people with dementia.
Methods:
Data sources were identified by searching PubMed, MEDLINE, Embase, psychINFO, and Cochrane Reviews Library. A total of 7,354 articles were identified, and of these, 30 RCTs were selected based on the selection criteria. Of these 30 RCTs, 14 were finally included in our meta-analysis [731 participants with dementia; 412 received CS (CS group) and 319 received usual care (control group)].
Results:
We found that the people with dementia had a moderate benefit from CS. The mean difference between the CS and control groups was 2.21 [95% CI (0.93, 3.49), Z=3.38, p=0.00007] in the Alzheimer's Disease Assessment Scale-Cognition and 1.41 [95% CI (0.98, 1.84), Z=6.39, p<0.00001] in the Mini-Mental State Examination. CS also improved quality of life in people with dementia [95% CI (0.72, 3.38), Z=3.02, p=0.003].
Conclusion:
CS is effective for improving cognition and quality of life in people with dementia; however, its effects were small to moderate.
Citing Articles
Cognitive stimulation to improve cognitive functioning in people with dementia.
Woods B, Rai H, Elliott E, Aguirre E, Orrell M, Spector A
Cochrane Database Syst Rev. 2025; 1():CD005562.
PMID: 39804128
PMC: 9891430.
DOI: 10.1002/14651858.CD005562.pub3.
Virtual reality cognitive remediation tool for individuals with mild cognitive impairment: study protocol for a feasibility randomized clinical trial.
Perra A, Primavera D, Leonetti V, Montisci R, Carta D, Lorrai G
Front Public Health. 2024; 12:1477279.
PMID: 39651467
PMC: 11622698.
DOI: 10.3389/fpubh.2024.1477279.
Effectiveness of Different Neurocognitive Intervention Approaches on Functionality in Healthy Older Adults: A Systematic Review.
Saez-Gutierrez S, Fernandez-Rodriguez E, Sanchez-Gomez C, Garcia-Martin A, Polo-Ferrero L, Barbero-Iglesias F
Behav Sci (Basel). 2024; 14(2).
PMID: 38392440
PMC: 10886235.
DOI: 10.3390/bs14020087.
The Molecular Effects of Environmental Enrichment on Alzheimer's Disease.
Liew A, Teo C, Soga T
Mol Neurobiol. 2022; 59(12):7095-7118.
PMID: 36083518
PMC: 9616781.
DOI: 10.1007/s12035-022-03016-w.
The Effectiveness of Computerized Cognitive Training Combined With Whole Body Cryotherapy in Improving Cognitive Functions in Older Adults. A Case Control Study.
Senczyszyn A, Wallner R, Szczesniak D, Luc M, Rymaszewska J
Front Psychiatry. 2021; 12:649066.
PMID: 34248698
PMC: 8267365.
DOI: 10.3389/fpsyt.2021.649066.
Computerized cognitive stimulation for people with dementia or with mild cognitive impairment: a bibliometric review.
Sobral S, Sobral M
Dement Neuropsychol. 2021; 15(1):28-40.
PMID: 33907595
PMC: 8049572.
DOI: 10.1590/1980-57642021dn15-020003.
Age- and cognition-related differences in the gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis.
Mulholland M, Sherwood C, Schapiro S, Raghanti M, Hopkins W
Am J Primatol. 2021; 83(11):e23264.
PMID: 33899958
PMC: 8546025.
DOI: 10.1002/ajp.23264.
The Effect of Cognitive Intervention on Cognitive Function in Older Adults With Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Wang Y, Yang L, Zhang J, Zeng X, Wang Y, Jin Y
Neuropsychol Rev. 2021; 32(2):247-273.
PMID: 33893905
DOI: 10.1007/s11065-021-09486-4.
Predicting the outcome of non-pharmacological treatment for patients with dementia-related mild cognitive impairment.
Shigihara Y, Hoshi H, Poza J, Rodriguez-Gonzalez V, Gomez C, Kanzawa T
Aging (Albany NY). 2020; 12(23):24101-24116.
PMID: 33289701
PMC: 7762505.
DOI: 10.18632/aging.202270.
Combining cognitive stimulation therapy and fall prevention exercise (CogEx) in older adults with mild to moderate dementia: a feasibility randomised controlled trial.
Binns E, Kerse N, Peri K, Cheung G, Taylor D
Pilot Feasibility Stud. 2020; 6:108.
PMID: 32724661
PMC: 7382095.
DOI: 10.1186/s40814-020-00646-6.
Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews.
Gavelin H, Lampit A, Hallock H, Sabates J, Bahar-Fuchs A
Neuropsychol Rev. 2020; 30(2):167-193.
PMID: 32266520
PMC: 7305099.
DOI: 10.1007/s11065-020-09434-8.
Effectiveness of a Combined Intervention on Psychological and Physical Capacities of Frail Older Adults: A Cluster Randomized Controlled Trial.
Apostolo J, Dos Anjos Dixe M, Bobrowicz-Campos E, Areosa T, Santos-Rocha R, Brauna M
Int J Environ Res Public Health. 2019; 16(17).
PMID: 31466229
PMC: 6747215.
DOI: 10.3390/ijerph16173125.
Editorial: Nonpharmacological Treatment of Cognitive Impairment.
Morley J, Berg-Weger M, Lundy J
J Nutr Health Aging. 2018; 22(6):632-633.
PMID: 29806850
DOI: 10.1007/s12603-018-1036-2.