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Cognitive Stimulation As a Therapeutic Modality for Dementia: A Meta-Analysis

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Specialty Psychiatry
Date 2017 Oct 19
PMID 29042888
Citations 12
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Abstract

Objective: Although cognitive stimulation (CS) is one of the most popular non-pharmacological interventions for people with dementia, its efficacy is still debatable. We performed a meta-analysis of randomized controlled trials (RCTs) on the efficacy of CS in people with dementia.

Methods: Data sources were identified by searching PubMed, MEDLINE, Embase, psychINFO, and Cochrane Reviews Library. A total of 7,354 articles were identified, and of these, 30 RCTs were selected based on the selection criteria. Of these 30 RCTs, 14 were finally included in our meta-analysis [731 participants with dementia; 412 received CS (CS group) and 319 received usual care (control group)].

Results: We found that the people with dementia had a moderate benefit from CS. The mean difference between the CS and control groups was 2.21 [95% CI (0.93, 3.49), Z=3.38, p=0.00007] in the Alzheimer's Disease Assessment Scale-Cognition and 1.41 [95% CI (0.98, 1.84), Z=6.39, p<0.00001] in the Mini-Mental State Examination. CS also improved quality of life in people with dementia [95% CI (0.72, 3.38), Z=3.02, p=0.003].

Conclusion: CS is effective for improving cognition and quality of life in people with dementia; however, its effects were small to moderate.

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References
1.
Lyketsos C, Steinberg M, Tschanz J, Norton M, Steffens D, Breitner J . Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000; 157(5):708-14. DOI: 10.1176/appi.ajp.157.5.708. View

2.
Stern Y, Moeller J, Anderson K, Luber B, Zubin N, DiMauro A . Different brain networks mediate task performance in normal aging and AD: defining compensation. Neurology. 2000; 55(9):1291-7. DOI: 10.1212/wnl.55.9.1291. View

3.
Cohen-Mansfield J . Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique. Am J Geriatr Psychiatry. 2001; 9(4):361-81. View

4.
Wilson R, Mendes de Leon C, Barnes L, Schneider J, Bienias J, Evans D . Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA. 2002; 287(6):742-8. DOI: 10.1001/jama.287.6.742. View

5.
Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View