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Adult Reference Intervals for IgG Subclasses with Siemens Immunonephelometric Assays in Chinese Population

Overview
Journal Allergy Asthma Clin Immunol
Specialty Allergy & Immunology
Date 2017 Oct 19
PMID 29042863
Citations 4
Authors
Ping Li
Zhongjuan Liu
Ziyan Wu
Xiaoting Wen
Liubing Li
Shulan Zhang
Yingchun Xu
Yongzhe Li
Affiliations
Soon will be listed here.
Abstract

Objective: To determine the adult reference intervals for the Siemens IgG subclass reagents.

Methods: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits.

Results: IgGSc reference intervals were as follows: IgG1 4.45-9.76 g/L, IgG2 2.07-8.57 g/L, IgG3 0.08-0.80 g/L and IgG4 0.05-1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed.

Conclusions: Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.

Citing Articles

Clinical Performance of Immunonephelometric Assay and Chemiluminescent Immunoassay for Detection of IgG Subclasses in Chinese.

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PMID: 38563457 PMC: 11073813. DOI: 10.1002/jcla.25033.

Clinical Significance of Serum IgG4 in the Diagnosis and Treatment Response of IgG4-Related Disease in Adults of Southwest China: A Retrospective Study.

Wei B, Guo Y, Ou X, Lin L, Su Z, Li L Ann Lab Med. 2023; 43(5):461-469.

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Serum IgG level is a predicting factor for the response to neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma.

Nakaya S, Ogawa R, Hayakawa S, Fujihata S, Okubo T, Sagawa H World J Surg Oncol. 2021; 19(1):217.

PMID: 34281546 PMC: 8290605. DOI: 10.1186/s12957-021-02290-7.

A reference interval for serum IgG subclasses in Chinese children.

Liu Z, Deng C, Li P, Wang J, Ma L, Li Y PLoS One. 2018; 13(3):e0192923.

PMID: 29505563 PMC: 5837086. DOI: 10.1371/journal.pone.0192923.

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