Permeability and Calcium Signaling in Lung Endothelium: Unpack the Box…

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2017 Oct 18

PMID 29040024

Citations 6

Authors

Mary I Townsley

Affiliations

Soon will be listed here.

Abstract

This brief review assesses the role of Ca signaling in lung endothelium in regulation of endothelial permeability. The disconnect between experimental and clinical outcomes to date may be due, in part, to the use of tools which yield information about aggregate permeability or Ca responses in lung or in endothelial monolayers. The teaching point of this review is to "unpack the box," i.e. consider the many potential issues which could impact interpretation of outcomes. These include phenotypic heterogeneity and resultant segment-specific permeability responses, methodologic issues related to permeability measures, contributions from Ca channels in cells other than endothelium-such as alveolar macrophages or blood leukocytes), Ca dynamic patterns, rather than averaged Ca responses to channel activation, and the background context, such as changes in endothelial bioenergetics with sepsis. Any or all of these issues might color interpretation of permeability and Ca signaling in lung.

Citing Articles

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