Deletion of a Homeobox Gene in Myeloid Leukemias with a Deletion in Chromosome 2

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1988 Nov 15

PMID 2903738

Citations 5

Authors

C Blatt

L Sachs

Affiliations

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Abstract

Mouse myeloid leukemias are characterized by a frequent deletion in one chromosome number 2. We now show that there is a deletion of one copy of the Hox-4.1 homeobox gene in the myeloid leukemias with this deletion in chromosome 2. It is suggested that deletion of this homeobox gene plays a role in determining the abnormal developmental program in myeloid leukemia.

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