Validation of Therapeutic Anti-inflammatory Potential of - A Traditional Formulation of

Overview

Journal J Tradit Complement Med

Specialty Rehabilitation Medicine

Date 2017 Oct 17

PMID 29034188

Citations 5

Authors

Nivedita Dube

Chetan Nimgulkar

Dinesh Kumar Bharatraj

Affiliations

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Abstract

(AKP), a traditional formulation of (. ) bark powder is used for its cardioprotective effects. However, its anti-inflammatory efficacy remained unexplored. In the present study, AKP was prepared in cow milk (as per standard procedure) and compared with standard hydroalcoholic extract (HA) of . . The extracts were analyzed for gross phytoconstituents levels, and their antioxidant activity was assayed by DPPH free radical scavenging activity and inhibition of lipid peroxidation. The anti-inflammatory activity of AKP and HA was studied in carrageenan-induced hind paw biphasic edema in C57BL/6 mice (at 200, 400 and 800 mg/kg BW). The percentage extraction yield of AKP was two folds higher than HA implying that the phytoconstituents in AKP were diluted by a factor of 0.5. The total polyphenol content of HA was (3.8 times) higher than AKP and the antioxidant activity of HA was also higher compared to AKP. Both the extracts, however, showed significant (p < 0.05) anti-inflammatory activity in reducing paw edema in mice. The efficacy of HA was more than AKP at early phase of inflammation, whereas, in the late phase of inflammation AKP was more efficacious and equipotent to HA. Thus, regardless of low antioxidant activity, AKP exhibited potential anti-inflammatory activity. The higher efficacy of AKP could be due to the presence of milk solids. These milk solids may act as adjuvants to 's phytoconstituents, contributing to their sustained bioavailability, leading to higher anti-inflammatory efficacy at lower drug concentrations.

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