Advances in MicroRNA Analysis

Overview

Journal Anal Bioanal Chem

Specialty Chemistry

Date 2017 Oct 17

PMID 29032457

Citations 24

Authors

Despina P Kalogianni

Panagiota M Kalligosfyri

Iraklis K Kyriakou

Theodore K Christopoulos

Affiliations

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Abstract

MicroRNAs (miRNAs) are single-stranded noncoding RNA molecules that act as key regulators of mRNA expression and are emerging biomarkers for disease. Their small size (18-25 nt) presents challenges to molecular recognition, labeling, and signal generation. Recent research activity in this field has aimed at the development of methods for miRNA quantification that combine high detectability, broad dynamic range, practicality, multiplexity, and low cost for prospective applications in diagnostic laboratories. This review article covers the most recent advances in microRNA analysis.

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