In Vitro Enhancement of Human Platelet Aggregation by Somatostatin

Overview

Journal Experientia

Specialty Science

Date 1988 Oct 15

PMID 2903069

Citations 1

Authors

P P Gazzaniga

G DI MACCO

R La Mancusa

A Oddi

G Pappalardo

F M Pulcinelli

D Reggio

Affiliations

Soon will be listed here.

Abstract

Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets.

Citing Articles

Somatostatin in acute bleeding oesophageal varices. Pharmacology and rationale for use.

Hanisch E, Doertenbach J, Usadel K Drugs. 1992; 44 Suppl 2:24-35; discussion 70-2.

PMID: 1385068 DOI: 10.2165/00003495-199200442-00005.

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