Review of the Potential Use of Blood Neuro-biomarkers in the Diagnosis of Mild Traumatic Brain Injury

Overview

Journal Clin Exp Emerg Med

Specialty Emergency Medicine

Date 2017 Oct 14

PMID 29026884

Citations 12

Authors

Alastair Jones

Paul Jarvis

Affiliations

Soon will be listed here.

Abstract

Head injury is a common presenting complaint amongst emergency department patients. To date, there has been no widespread utilization of neuro-biomarkers to aid the diagnosis of traumatic brain injury. This review article explores which neuro-biomarkers could be used in the emergency department in aiding the clinical diagnosis of mild traumatic brain injury. Based on the available evidence, the most promising neuro-biomarkers appear to be Glial fibrillary acidic protein (GFAP) and Ubiquitin C-Terminal Hydrolase Isozyme L1 (UCH-L1) as these show significant rises in peripheral blood levels shortly after injury and these have been demonstrated to correlate with long-term clinical outcomes. Treatment strategies for minor traumatic brain injury in the emergency department setting are not well developed. The introduction of blood neuro-biomarkers could reduce unnecessary radiation exposure and provide an opportunity to improve the care of this patient group.

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