History of Concussion Impacts Electrophysiological Correlates of Working Memory

Overview

Journal Int J Psychophysiol

Publisher Elsevier

Specialty Psychiatry

Date 2017 Oct 13

PMID 29024682

Citations 6

Authors

Caitlin M Hudac

Cathryn S Cortesa

Patrick S Ledwidge

Dennis L Molfese

Affiliations

Soon will be listed here.

Abstract

Sports-related concussions occur in approximately 21% of college athletes with implications for long-term cognitive impairments in working memory. Working memory involves the capacity to maintain short-term information and integrate with higher-order cognitive processing for planning and behavior execution, critical skills for optimal cognitive and athletic performance. This study quantified working memory impairments in 36 American football college athletes (18-23years old) using event-related potentials (ERPs). Despite performing similarly in a standard 2-back working memory task, athletes with history of concussion exhibited larger P1 and P3 amplitudes compared to Controls. Concussion History group latencies were slower for the P1 and faster for the N2. Source estimation analyses indicated that previously concussed athletes engaged different brain regions compared to athletes with no concussion history. These findings suggest that ERPs may be a sensitive and objective measure to detect long-term cognitive consequences of concussion.

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References

Gosselin N, Lassonde M, Petit D, Leclerc S, Mongrain V, Collie A . Sleep following sport-related concussions. Sleep Med. 2008; 10(1):35-46. DOI: 10.1016/j.sleep.2007.11.023. View

Langlois J, Rutland-Brown W, Wald M . The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006; 21(5):375-8. DOI: 10.1097/00001199-200609000-00001. View

Ungerleider L, Courtney S, Haxby J . A neural system for human visual working memory. Proc Natl Acad Sci U S A. 1998; 95(3):883-90. PMC: 33812. DOI: 10.1073/pnas.95.3.883. View

Webb S, Bernier R, Henderson H, Johnson M, Jones E, Lerner M . Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism. J Autism Dev Disord. 2013; 45(2):425-43. PMC: 4141903. DOI: 10.1007/s10803-013-1916-6. View

Ferree T, Eriksen K, Tucker D . Regional head tissue conductivity estimation for improved EEG analysis. IEEE Trans Biomed Eng. 2000; 47(12):1584-92. DOI: 10.1109/10.887939. View

Gaetz M, Goodman D, WEINBERG H . Electrophysiological evidence for the cumulative effects of concussion. Brain Inj. 2001; 14(12):1077-88. DOI: 10.1080/02699050050203577. View

Rossini P, Cracco R, Cracco J, House W . Short latency somatosensory evoked potentials to peroneal nerve stimulation: scalp topography and the effect of different frequency filters. Electroencephalogr Clin Neurophysiol. 1981; 52(6):540-52. DOI: 10.1016/0013-4694(81)91429-2. View

Matser E, Kessels A, Lezak M, Jordan B, Troost J . Neuropsychological impairment in amateur soccer players. JAMA. 1999; 282(10):971-3. DOI: 10.1001/jama.282.10.971. View

Koenigs M, Barbey A, Postle B, Grafman J . Superior parietal cortex is critical for the manipulation of information in working memory. J Neurosci. 2009; 29(47):14980-6. PMC: 2799248. DOI: 10.1523/JNEUROSCI.3706-09.2009. View

10.

Eimer M, Goschke T, Schlaghecken F, Sturmer B . Explicit and implicit learning of event sequences: evidence from event-related brain potentials. J Exp Psychol Learn Mem Cogn. 1996; 22(4):970-87. DOI: 10.1037//0278-7393.22.4.970. View

11.

Keightley M, Saluja R, Chen J, Gagnon I, Leonard G, Petrides M . A functional magnetic resonance imaging study of working memory in youth after sports-related concussion: is it still working?. J Neurotrauma. 2013; 31(5):437-51. PMC: 3934544. DOI: 10.1089/neu.2013.3052. View

12.

Rugg M, Cowan C, NAGY M, Milner A, Jacobson I, Brooks D . Event related potentials from closed head injury patients in an auditory "oddball" task: evidence of dysfunction in stimulus categorisation. J Neurol Neurosurg Psychiatry. 1988; 51(5):691-8. PMC: 1033079. DOI: 10.1136/jnnp.51.5.691. View

13.

Collie A, Makdissi M, Maruff P, Bennell K, McCrory P . Cognition in the days following concussion: comparison of symptomatic versus asymptomatic athletes. J Neurol Neurosurg Psychiatry. 2006; 77(2):241-5. PMC: 2077582. DOI: 10.1136/jnnp.2005.073155. View

14.

Sohlberg M, Ledbetter A . Management of Persistent Cognitive Symptoms After Sport-Related Concussion. Am J Speech Lang Pathol. 2016; 25(2):138-49. DOI: 10.1044/2015_AJSLP-14-0128. View

15.

McAllister T, Sparling M, Flashman L, Guerin S, Mamourian A, Saykin A . Differential working memory load effects after mild traumatic brain injury. Neuroimage. 2001; 14(5):1004-12. DOI: 10.1006/nimg.2001.0899. View

16.

Klimesch W, Sauseng P, Hanslmayr S, Gruber W, Freunberger R . Event-related phase reorganization may explain evoked neural dynamics. Neurosci Biobehav Rev. 2007; 31(7):1003-16. DOI: 10.1016/j.neubiorev.2007.03.005. View

17.

Klimesch W, Sauseng P, Hanslmayr S . EEG alpha oscillations: the inhibition-timing hypothesis. Brain Res Rev. 2006; 53(1):63-88. DOI: 10.1016/j.brainresrev.2006.06.003. View

18.

Moore R, Pindus D, Drolette E, Scudder M, Raine L, Hillman C . The persistent influence of pediatric concussion on attention and cognitive control during flanker performance. Biol Psychol. 2015; 109:93-102. DOI: 10.1016/j.biopsycho.2015.04.008. View

19.

Broglio S, Moore R, Hillman C . A history of sport-related concussion on event-related brain potential correlates of cognition. Int J Psychophysiol. 2011; 82(1):16-23. DOI: 10.1016/j.ijpsycho.2011.02.010. View

20.

Polich J . Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol. 2007; 118(10):2128-48. PMC: 2715154. DOI: 10.1016/j.clinph.2007.04.019. View