Successful Treatment of a Case of Late-onset Colitis After Umbilical Cord Transplantation with Metronidazole: A Case Report and Literature Review

Overview

Journal Intern Med

Specialty General Medicine

Date 2017 Oct 13

PMID 29021466

Citations 1

Authors

Reona Sakemura

Hiroshi Hayakawa

Hiroatsu Iida

Masafumi Ito

Tomohiro Kajiguchi

Affiliations

Soon will be listed here.

Abstract

Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. We encountered a case similar to CCS that developed severe watery diarrhea after UCBT without any signs of GVHD or infection and responded well to metronidazole (MNZ) treatment. Since CCS is very rare, we herein describe a case of MNZ-effective diarrhea after UCBT.

Citing Articles

Metronidazole-induced encephalopathy during treatment for refractory diarrhea after cord blood transplantation.

Iemura T, Kitano T, Ishii A, Hishizawa M, Kondo T, Yamashita K Clin J Gastroenterol. 2019; 12(5):414-419.

PMID: 30835083 DOI: 10.1007/s12328-019-00959-x.

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