Autophagy Proteins in Phagocyte Endocytosis and Exocytosis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2017 Oct 12

PMID 29018446

Citations 10

Authors

Christian Munz

Affiliations

Soon will be listed here.

Abstract

Autophagy was initially described as a catabolic pathway that recycles nutrients of cytoplasmic constituents after lysosomal degradation during starvation. Since the immune system monitors products of lysosomal degradation major histocompatibility complex (MHC) class II restricted antigen presentation, autophagy was found to process intracellular antigens for display on MHC class II molecules. In recent years, however, it has become apparent that the molecular machinery of autophagy serves phagocytes in many more membrane trafficking pathways, thereby regulating immunity to infectious disease agents. In this minireview, we will summarize the recent evidence that autophagy proteins regulate phagocyte endocytosis and exocytosis for myeloid cell activation, pathogen replication, and MHC class I and II restricted antigen presentation. Selective stimulation and inhibition of the respective functional modules of the autophagy machinery might constitute valid therapeutic options in the discussed disease settings.

Citing Articles

Association of Glial Activation and α-Synuclein Pathology in Parkinson's Disease.

Wang R, Ren H, Kaznacheyeva E, Lu X, Wang G Neurosci Bull. 2022; 39(3):479-490.

PMID: 36229715 PMC: 10043108. DOI: 10.1007/s12264-022-00957-z.

RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages.

Valecka J, Camosseto V, McEwan D, Terawaki S, Liu Z, Strock E R Soc Open Sci. 2021; 8(7):202333.

PMID: 34295519 PMC: 8278043. DOI: 10.1098/rsos.202333.

The Interplay of Host Lysosomes and Intracellular Pathogens.

Sachdeva K, Sundaramurthy V Front Cell Infect Microbiol. 2020; 10:595502.

PMID: 33330138 PMC: 7714789. DOI: 10.3389/fcimb.2020.595502.

Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses.

Zhang Y, Chen Z Cells. 2020; 9(12).

PMID: 33266087 PMC: 7760648. DOI: 10.3390/cells9122562.

Sublethal Levels of Antibiotics Promote Bacterial Persistence in Epithelial Cells.

Liu X, Liu F, Ding S, Shen J, Zhu K Adv Sci (Weinh). 2020; 7(18):1900840.

PMID: 32999821 PMC: 7509632. DOI: 10.1002/advs.201900840.

References

Li Y, Wang L, Yang G, Hao F, Urba W, Hu H . Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res. 2008; 68(17):6889-95. PMC: 2905686. DOI: 10.1158/0008-5472.CAN-08-0161. View

Pallet N, Sirois I, Bell C, Hanafi L, Hamelin K, Dieude M . A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. Proteomics. 2013; 13(7):1108-20. DOI: 10.1002/pmic.201200531. View

Zhou R, Yazdi A, Menu P, Tschopp J . A role for mitochondria in NLRP3 inflammasome activation. Nature. 2010; 469(7329):221-5. DOI: 10.1038/nature09663. View

Dasari V, Rehan S, Tey S, Smyth M, Smith C, Khanna R . Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells. Immunol Cell Biol. 2016; 94(10):964-974. DOI: 10.1038/icb.2016.59. View

Lee H, Mattei L, Steinberg B, Alberts P, Lee Y, Chervonsky A . In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity. 2010; 32(2):227-39. PMC: 2996467. DOI: 10.1016/j.immuni.2009.12.006. View

Dales S, Eggers H, Tamm I, Palade G . ELECTRON MICROSCOPIC STUDY OF THE FORMATION OF POLIOVIRUS. Virology. 1965; 26:379-89. DOI: 10.1016/0042-6822(65)90001-2. View

Rogov V, Dotsch V, Johansen T, Kirkin V . Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol Cell. 2014; 53(2):167-78. DOI: 10.1016/j.molcel.2013.12.014. View

Henault J, Martinez J, Riggs J, Tian J, Mehta P, Clarke L . Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. 2012; 37(6):986-997. PMC: 3786711. DOI: 10.1016/j.immuni.2012.09.014. View

Li Y, Hahn T, Garrison K, Cui Z, Thorburn A, Thorburn J . The vitamin E analogue α-TEA stimulates tumor autophagy and enhances antigen cross-presentation. Cancer Res. 2012; 72(14):3535-45. PMC: 3576035. DOI: 10.1158/0008-5472.CAN-11-3103. View

10.

Huang J, Canadien V, Lam G, Steinberg B, Dinauer M, Magalhaes M . Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A. 2009; 106(15):6226-31. PMC: 2664152. DOI: 10.1073/pnas.0811045106. View

11.

Buckingham E, Carpenter J, Jackson W, Grose C . Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity. J Virol. 2013; 88(2):890-902. PMC: 3911683. DOI: 10.1128/JVI.02646-13. View

12.

Gutierrez M, Master S, Singh S, Taylor G, Colombo M, Deretic V . Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004; 119(6):753-66. DOI: 10.1016/j.cell.2004.11.038. View

13.

Xing Y, Cao R, Hu H . TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles). Cell Death Dis. 2016; 7(8):e2322. PMC: 5108312. DOI: 10.1038/cddis.2016.206. View

14.

Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M . Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017; 114(27):7142-7147. PMC: 5502639. DOI: 10.1073/pnas.1705235114. View

15.

Florey O, Kim S, Sandoval C, Haynes C, Overholtzer M . Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol. 2011; 13(11):1335-43. PMC: 3223412. DOI: 10.1038/ncb2363. View

16.

Tsukada M, Ohsumi Y . Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 1993; 333(1-2):169-74. DOI: 10.1016/0014-5793(93)80398-e. View

17.

Bustos V, Pulina M, Bispo A, Lam A, Flajolet M, Gorelick F . Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2017; 114(27):7148-7153. PMC: 5502640. DOI: 10.1073/pnas.1705240114. View

18.

Beale R, Wise H, Stuart A, Ravenhill B, Digard P, Randow F . A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host Microbe. 2014; 15(2):239-47. PMC: 3991421. DOI: 10.1016/j.chom.2014.01.006. View

19.

Ma J, Becker C, Lowell C, Underhill D . Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012; 287(41):34149-56. PMC: 3464523. DOI: 10.1074/jbc.M112.382812. View

20.

Henderson D, Conner S . A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. Mol Biol Cell. 2007; 18(7):2698-706. PMC: 1924820. DOI: 10.1091/mbc.e06-09-0831. View