Solid Phase Deracemization of an Atropisomer

Overview

Journal Cryst Growth Des

Publisher American Chemical Society

Date 2017 Oct 12

PMID 29018306

Citations 1

Authors

Anthonius H J Engwerda

Pim van Schayik

Henjo Jagtenberg

Hugo Meekes

Floris P J T Rutjes

Elias Vlieg

Affiliations

Soon will be listed here.

Abstract

The scope of Viedma ripening and temperature cycling with respect to chiral molecules has remained mostly limited to molecules with a single stereogenic center, while racemization proceeds through inversion at that particular stereocenter. In this article we demonstrate for the first time that atropisomers, chiral rotamers that possess an axis of chirality, can be successfully deracemized in the solid phase by either applying temperature cycling or Viedma ripening.

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