Epidemiology and Antifungal Susceptibility of Candidemia Isolates of Non-albicans Candida Species from Cancer Patients

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2017 Oct 12

PMID 29018251

Citations 43

Authors

Ping-Feng Wu

Wei-Lun Liu

Min-Han Hsieh

Ing-Moi Hii

Yu-Lin Lee

Yi-Tsung Lin

Mao-Wang Ho

Chun-Eng Liu

Yen-Hsu Chen

Fu-Der Wang

Affiliations

Soon will be listed here.

Abstract

Candidemia is a growing concern worldwide, and its species distribution has shifted toward non-albicans Candida in recent decades, especially in patients with malignancy. This study aimed to update the epidemiology and antifungal susceptibility of non-albicans candidemia isolates from the cancer patients. Adult cancer patients with non-albicans candidemia were recruited, and clinical data were retrospectively collected from five medical centers in Taiwan from 1 July 2011 to 30 June 2014. In vitro susceptibility was determined by the broth dilution method using a Sensititre YeastOne system and interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. A total of 346 episodes of non-albicans candidemia were identified in cancer patients. Candida tropicalis was the most common species (n=145, 41.9%) and had the highest resistance rate to fluconazole (n=17, 13.9%) among all the preserved isolates, including C. tropicalis, Candida glabrata and Candida parapsilosis. A higher Charlson comorbidity index, non-albicans candidemia due to C. tropicalis, neutropenia and septic shock were independent predictors of 28-day mortality. In conclusion, the species distribution and antifungal susceptibility of non-albicans candidemia isolates in our study differed from those in Western countries, providing useful information about local epidemiology for the selection of empirical antifungal agents for cancer patients.

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