Progress Towards a Vaccine Against Enterotoxigenic Escherichia Coli

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 1988 Apr 1

PMID 2898844

Citations 8

Authors

J B Kaper

M M Levine

Affiliations

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Abstract

A variety of approaches are being investigated in the development of a vaccine against enterotoxigenic Escherichia coli (ETEC). These approaches include purified fimbriae vaccines, toxoid vaccines, live attenuated E. coli vaccine strains and ETEC antigens expressed in carrier organisms. Studies of the pathogenesis and immune response to ETEC indicate that development of a vaccine against human ETEC is a realistic goal but considerable work remains before this goal is realized.

Citing Articles

Construction of a novel Shigella live-vector strain co-expressing CS3 and LTB/STm of enterotoxigenic E.coli.

Zheng J, Zhang Z, Li S, Liu X, Yuan S, Wang P World J Gastroenterol. 2005; 11(22):3411-8.

PMID: 15948247 PMC: 4315996. DOI: 10.3748/wjg.v11.i22.3411.

Genotyping of fimbrial adhesins in Escherichia coli strains isolated from Slovak piglets suffering from diarrhea.

Vu-Khac H, Holoda E, Majerciak M, Gaspar G, Pilipcinec E Folia Microbiol (Praha). 2004; 49(1):59-63.

PMID: 15114867 PMC: 7090526. DOI: 10.1007/BF02931647.

Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxin.

Fleckenstein J, Lindler L, Elsinghorst E, Dale J Infect Immun. 2000; 68(5):2766-74.

PMID: 10768971 PMC: 97486. DOI: 10.1128/IAI.68.5.2766-2774.2000.

Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli.

Fleckenstein J, Kopecko D, Warren R, Elsinghorst E Infect Immun. 1996; 64(6):2256-65.

PMID: 8675335 PMC: 174064. DOI: 10.1128/iai.64.6.2256-2265.1996.

Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR.

Wu S, Pascual D, Vancott J, McGhee J, Maneval Jr D, Levine M Infect Immun. 1995; 63(12):4933-8.

PMID: 7591160 PMC: 173709. DOI: 10.1128/iai.63.12.4933-4938.1995.