Role of Cell Cycle Regulators in Adipose Tissue and Whole Body Energy Homeostasis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Oct 9

PMID 28988292

Citations 19

Authors

I C Lopez-Mejia

J Castillo-Armengol

S Lagarrigue

L Fajas

Affiliations

Soon will be listed here.

Abstract

In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.

Citing Articles

A Closer Look into White Adipose Tissue Biology and the Molecular Regulation of Stem Cell Commitment and Differentiation.

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Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.

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Comprehensive Analysis of circRNA Expression Profiles in Human Brown Adipose Tissue.

Sun X, Wan X, Khan M, Zhang K, Yi X, Wang Z Diabetes Metab Syndr Obes. 2023; 16:469-478.

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The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis.

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