Progression Level of Extracapsular Spread and Tumor Budding for Cervical Lymph Node Metastasis of OSCC

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2017 Oct 8

PMID 28986696

Citations 6

Authors

Shin-Ichi Yamada

Mitsunobu Otsuru

Souichi Yanamoto

Takumi Hasegawa

Hitoshi Aizawa

Takahiro Kamata

Nobuhiro Yamakawa

Tomoyuki Kohgo

Akira Ito

Yuri Noda

Chihoko Hirai

Tetsuya Kitamura

Masaya Okura

Tadaaki Kirita

Michihiro Ueda

Tetsuro Yamashita

Yoshihide Ota

Takahide Komori

Masahiro Umeda

Hiroshi Kurita

Affiliations

Soon will be listed here.

Abstract

Objectives: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined.

Patients And Methods: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis.

Results: ECS was detected in 216 cases of OSCC and analyzed. The 5-year overall survival and RFS rates of patients with type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, were significantly poor at 40.6 and 37.8%, respectively. The results of a univariate analysis suggested that the prognosis of ECS in OSCC patients is associated with its progression level, particularly type C. The 5-year RFS rate of type C with tumor budding was significantly poor at 31.5%. Type C with tumor budding correlated with local and regional recurrence as well as distant metastasis. In a multivariate analysis, tumor budding was identified as an independent prognostic factor.

Conclusions: These results suggest that the progression level of ECS and tumor budding are useful prognostic factors in OSCC patients.

Clinical Relevance: This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.

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