Gender Differences in the Prevalence of Congenital Heart Disease in Down's Syndrome: a Brief Meta-analysis

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2017 Oct 8

PMID 28985718

Citations 17

Authors

Tereza Cristina Pinheiro Diogenes

Felipe Alves Mourato

Jose Luiz de Lima Filho

Sandra da Silva Mattos

Affiliations

Soon will be listed here.

Abstract

Background: Down's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.

Methods: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.

Results: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.

Conclusion: CHD, particularly AVSD, are more common in the female gender of Down's syndrome patients.

Citing Articles

Prevalence and risk factors analysis of early postoperative arrhythmia after congenital heart surgery in pediatric patients.

Yasa K, Katritama A, Harta I, Sudarma I J Arrhythm. 2024; 40(2):356-362.

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Gender and its association with cardiac defects in down syndrome population at Children Hospital & Institute of Child Health, Lahore, Pakistan.

Haider A, Khan S, Tafweez R, Yaqoob M Pak J Med Sci. 2024; 40(3Part-II):371-375.

PMID: 38356816 PMC: 10862423. DOI: 10.12669/pjms.40.3.7346.

Congenital Heart Defects and Outcome in a Large Cohort of Down Syndrome: A Single-Center Experience from Turkey.

Alkaya D, Ozturk B, Yuksel Ulker A, Bozlak S, Ozturk E, Dedeoglu R Turk Arch Pediatr. 2023; 58(5):473-479.

PMID: 37534463 PMC: 10544380. DOI: 10.5152/TurkArchPediatr.2023.23041.

Sex differences in cardiovascular disease and dysregulation in Down syndrome.

Bates M, Vasileva A, Flores L, Pryakhina Y, Buckman M, Tomasson M Am J Physiol Heart Circ Physiol. 2023; 324(4):H542-H552.

PMID: 36800509 PMC: 10042600. DOI: 10.1152/ajpheart.00544.2022.

[Congenital heart disease in Down's syndrome].

Arias-Lobo R, Lupinta-Paredes E, Calderon-Colmenero J, Cervantes-Salazar J, Garcia-Montes J, Patino-Bahena E Arch Cardiol Mex. 2023; 93(3):294-299.

PMID: 36634578 PMC: 10406475. DOI: 10.24875/ACM.22000053.

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