Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2017 Oct 7

PMID 28985560

Citations 2853

Authors

Brent R Stockwell

Jose Pedro Friedmann Angeli

Hulya Bayir

Ashley I Bush

Marcus Conrad

Scott J Dixon

Simone Fulda

Sergio Gascon

Stavroula K Hatzios

Valerian E Kagan

Kay Noel

Xuejun Jiang

Andreas Linkermann

Maureen E Murphy

Michael Overholtzer

Atsushi Oyagi

Gabriela C Pagnussat

Jason Park

Qitao Ran

Craig S Rosenfeld

Konstantin Salnikow

Daolin Tang

Frank M Torti

Suzy V Torti

Shinya Toyokuni

K A Woerpel

Donna D Zhang

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q. Ferroptosis has been implicated in the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's, and Parkinson's diseases), carcinogenesis, stroke, intracerebral hemorrhage, traumatic brain injury, ischemia-reperfusion injury, and kidney degeneration in mammals and is also implicated in heat stress in plants. Ferroptosis may also have a tumor-suppressor function that could be harnessed for cancer therapy. This Primer reviews the mechanisms underlying ferroptosis, highlights connections to other areas of biology and medicine, and recommends tools and guidelines for studying this emerging form of regulated cell death.

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