ReMAPping the Microtubule Landscape: How Phosphorylation Dictates the Activities of Microtubule-associated Proteins

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2017 Oct 6

PMID 28980356

Citations 82

Authors

Amrita Ramkumar

Brigette Y Jong

Kassandra M Ori-McKenney

Affiliations

Soon will be listed here.

Abstract

Classical microtubule-associated proteins (MAPs) were originally identified based on their co-purification with microtubules assembled from mammalian brain lysate. They have since been found to perform a range of functions involved in regulating the dynamics of the microtubule cytoskeleton. Most of these MAPs play integral roles in microtubule organization during neuronal development, microtubule remodeling during neuronal activity, and microtubule stabilization during neuronal maintenance. As a result, mutations in MAPs contribute to neurodevelopmental disorders, psychiatric conditions, and neurodegenerative diseases. MAPs are post-translationally regulated by phosphorylation depending on developmental time point and cellular context. Phosphorylation can affect the microtubule affinity, cellular localization, or overall function of a particular MAP and can thus have profound implications for neuronal health. Here we review MAP1, MAP2, MAP4, MAP6, MAP7, MAP9, tau, and DCX, and how each is regulated by phosphorylation in neuronal physiology and disease. Developmental Dynamics 247:138-155, 2018. © 2017 Wiley Periodicals, Inc.

Citing Articles

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