Serum Leptin Level Positively Correlates with Metabolic Syndrome Among Elderly Taiwanese

Overview

Journal Tzu Chi Med J

Specialty General Medicine

Date 2017 Oct 5

PMID 28974910

Citations 8

Authors

Li-Hsuan Wang

Yao-Chang Liu

Ji-Hung Wang

Chung-Jen Lee

Bang-Gee Hsu

Affiliations

Soon will be listed here.

Abstract

Objective: Leptin is an adipocyte-derived hormone and has shown positive correlation with obesity and metabolic syndrome (MetS) in many studies. However, there are few studies investigating this relation in elderly people. Therefore, we aimed to investigate the correlation between the fasting serum leptin level and MetS among older Taiwanese.

Materials And Methods: The fasting serum leptin level was obtained from 62 Taiwanese participants over 65 years old and was measured using a commercially available enzyme immunoassay kit. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation.

Results: Thirty elderly participants (48.4%) had MetS. The serum leptin level was positively correlated with MetS ( < 0.001). Multivariate logistic regression analysis of the factors significantly associated with MetS showed that logarithmically transformed leptin (log-leptin, each increase 0.1 ng/mL log-leptin, odds ratio: 1.276, 95% confidence interval: 1.015-1.603, = 0.037) was still an independent predictor of MetS in elderly persons. Univariable linear analysis showed that body weight ( = 0280, = 0.028), body mass index ( = 0.417, = 0.001), waist circumference ( = 0.419, = 0.001), blood urea nitrogen ( = 0255, = 0.046), log-insulin ( = 0436, < 0.001), and logarithmically transformed homeostasis model assessment of insulin resistance ( = 0359, = 0.004) positively correlated with fasting serum log-leptin levels. Multivariate forward stepwise linear regression analysis of the factors significantly associated with fasting serum log-leptin levels revealed that waist circumference (adjusted = 0.083, = 0.002), statin use (adjusted = 0.058, = 0.016), and female gender (adjusted = 0.041, = 0.034) were independent predictors of fasting serum log-leptin levels among elderly participants.

Conclusion: In elderly Taiwanese, the serum leptin level was positively correlated with MetS. Waist circumference, statin use, and female gender were independent predictors of the fasting serum leptin level in elderly participants.

Citing Articles

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus.

Kamel S, Abdel Azeem Abd Elazeem M, Mohamed R, Kamel M, Abdel Aleem Abdelaleem E Int J Immunopathol Pharmacol. 2023; 37:3946320231154988.

PMID: 36718110 PMC: 9893074. DOI: 10.1177/03946320231154988.

Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross-sectional study.

Ofori E, Adekena C, Boima V, Asare-Anane H, Yorke E, Nyarko E Health Sci Rep. 2023; 6(1):e1053.

PMID: 36698704 PMC: 9851162. DOI: 10.1002/hsr2.1053.

Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome: A Review on Animal and Human Evidence.

Wong S Int J Med Sci. 2021; 18(12):2673-2688.

PMID: 34104100 PMC: 8176183. DOI: 10.7150/ijms.58147.

Association of serum leptin with angiographically proven cardiovascular disease and with components of the metabolic syndrome: a cross-sectional study in East Azerbaijan.

Khanbabaei N, Saadati H, Valizadeh Shahbazloo S, Hoseinpoor R, Naderi S, Taghvamanesh R Cardiovasc Endocrinol Metab. 2021; 10(1):45-50.

PMID: 33634255 PMC: 7901824. DOI: 10.1097/XCE.0000000000000227.

Risk Associated with the rs8179183 GG Genotype in a Female Korean Population with Obesity.

Jang K, Shin G, Yoo H, Lee J, Kim M Antioxidants (Basel). 2020; 9(6).

PMID: 32517169 PMC: 7346126. DOI: 10.3390/antiox9060497.

References

Wang J, Lee C, Hsieh J, Chen Y, Hsu B . Inverse association of long-acting natriuretic peptide with metabolic syndrome in congestive heart failure patients. Diabetol Metab Syndr. 2013; 5(1):19. PMC: 3635959. DOI: 10.1186/1758-5996-5-19. View

Sun Y, Li J, Luan Y, Wang L . Effect of statin therapy on leptin levels in patients with coronary heart disease. Peptides. 2010; 31(6):1205-7. DOI: 10.1016/j.peptides.2010.03.023. View

Monti V, Carlson J, Hunt S, Adams T . Relationship of ghrelin and leptin hormones with body mass index and waist circumference in a random sample of adults. J Am Diet Assoc. 2006; 106(6):822-8. DOI: 10.1016/j.jada.2006.03.015. View

Alberti K, Zimmet P . Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15(7):539-53. DOI: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. View

Alberti K, Zimmet P, Shaw J . Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5):469-80. DOI: 10.1111/j.1464-5491.2006.01858.x. View

Andreasson A, Unden A, Elofsson S, Brismar K . Leptin and adiponectin: distribution and associations with cardiovascular risk factors in men and women of the general population. Am J Hum Biol. 2012; 24(5):595-601. DOI: 10.1002/ajhb.22279. View

Askari H, Tykodi G, Liu J, Dagogo-Jack S . Fasting plasma leptin level is a surrogate measure of insulin sensitivity. J Clin Endocrinol Metab. 2010; 95(8):3836-43. PMC: 2913039. DOI: 10.1210/jc.2010-0296. View

Pecht T, Gutman-Tirosh A, Bashan N, Rudich A . Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans. Obes Rev. 2013; 15(4):322-37. DOI: 10.1111/obr.12133. View

Utzschneider K, Van de Lagemaat A, Faulenbach M, Goedecke J, Carr D, Boyko E . Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes. Obesity (Silver Spring). 2010; 18(9):1781-7. DOI: 10.1038/oby.2010.77. View

10.

Yun J, Kimm H, Jo J, Jee S . Serum leptin is associated with metabolic syndrome in obese and nonobese Korean populations. Metabolism. 2009; 59(3):424-9. DOI: 10.1016/j.metabol.2009.08.012. View

11.

Perez-Perez A, Maymo J, Gambino Y, Guadix P, Duenas J, Varone C . Insulin enhances leptin expression in human trophoblastic cells. Biol Reprod. 2013; 89(1):20. DOI: 10.1095/biolreprod.113.109348. View

12.

Ingelsson E, Larson M, Yin X, Wang T, Meigs J, Lipinska I . Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. J Clin Endocrinol Metab. 2008; 93(8):3149-57. PMC: 2515078. DOI: 10.1210/jc.2008-0207. View

13.

Guo S . Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol. 2013; 220(2):T1-T23. PMC: 4087161. DOI: 10.1530/JOE-13-0327. View

14.

Saravia G, Civeira F, Hurtado-Roca Y, Andres E, Leon M, Pocovi M . Glycated Hemoglobin, Fasting Insulin and the Metabolic Syndrome in Males. Cross-Sectional Analyses of the Aragon Workers' Health Study Baseline. PLoS One. 2015; 10(8):e0132244. PMC: 4524641. DOI: 10.1371/journal.pone.0132244. View

15.

Gannage-Yared M, Azar R, Amm-Azar M, Khalife S, Germanos-Haddad M, Neemtallah R . Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients. Metabolism. 2005; 54(7):947-51. DOI: 10.1016/j.metabol.2005.02.011. View

16.

Maeda T, Horiuchi N . Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. J Biochem. 2009; 145(6):771-81. DOI: 10.1093/jb/mvp035. View

17.

Esteghamati A, Khalilzadeh O, Anvari M, Rashidi A, Mokhtari M, Nakhjavani M . Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity. Metab Syndr Relat Disord. 2009; 7(5):447-52. DOI: 10.1089/met.2008.0100. View

18.

Mantzoros C, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno T, Kim S . Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011; 301(4):E567-84. PMC: 3191548. DOI: 10.1152/ajpendo.00315.2011. View

19.

Ble A, Windham B, Bandinelli S, Taub D, Volpato S, Bartali B . Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study). Am J Cardiol. 2005; 96(7):991-5. DOI: 10.1016/j.amjcard.2005.05.058. View

20.

Tsai J, Lee M, Le M, Chen Y, Ho G, Shih M . Hyperleptinemia Is a Risk Factor for the Development of Central Arterial Stiffness in Kidney Transplant Patients. Transplant Proc. 2015; 47(6):1825-30. DOI: 10.1016/j.transproceed.2015.06.002. View