Dysfunctional Gaze Processing in Bipolar Disorder

Overview

Journal Neuroimage Clin

Publisher Elsevier

Specialties Neurology
Radiology

Date 2017 Oct 4

PMID 28971006

Citations 7

Authors

Cristina Berchio

Camille Piguet

Christoph M Michel

Paolo Cordera

Tonia A Rihs

Alexandre G Dayer

Jean-Michel Aubry

Affiliations

Soon will be listed here.

Abstract

Gaze conveys emotional information, and humans present sensitivity to its direction from the earliest days of life. Bipolar disorder is a disease characterized by fluctuating states of emotional and cognitive dysregulation. To explore the role of attentional control on face processing in bipolar patients (BP) we used gaze direction as an emotion modulation parameter in a two-back Working Memory (WM) task while high-density EEG data were acquired. Since gaze direction influences emotional attributions to faces with neutral expressions as well, we presented neutral faces with direct and averted gaze. Nineteen euthymic BP and a sample of age- and gender-matched controls were examined. In BP we observed diminished P200 and augmented P300 evoked responses, differentially modulated by non-repeated or repeated faces, as well as by gaze direction. BP showed a reduced P200 amplitude, significantly stronger for faces with direct gaze than averted gaze. Source localization of P200 indicated decreased activity in sensory-motor regions and frontal areas suggestive of abnormal affective processing of neutral faces. The present study provides neurophysiological evidence for abnormal gaze processing in BP and suggests dysfunctional processing of direct eye contact as a prominent characteristic of bipolar disorder.

Citing Articles

EEG Spatial-temporal Dynamics of Resting-state Activity in Young Women with Anorexia Nervosa: Preliminary Evidence.

Berchio C, Kumar S, Micali N Brain Topogr. 2023; 37(3):447-460.

PMID: 37615798 DOI: 10.1007/s10548-023-01001-7.

Reductions in regional theta power and fronto-parietal theta-gamma phase-amplitude coupling during gaze processing in bipolar disorder.

Lasagna C, Grove T, Semple E, Suzuki T, Menkes M, Pamidighantam P Psychiatry Res Neuroimaging. 2023; 331:111629.

PMID: 36966619 PMC: 10567117. DOI: 10.1016/j.pscychresns.2023.111629.

EEG Biomarkers in Children and Adolescents With Feeding and Eating Disorders: Current Evidence and Future Directions.

Berchio C, Cambi S, Pappaianni E, Micali N Front Psychiatry. 2022; 13:882358.

PMID: 35463489 PMC: 9026170. DOI: 10.3389/fpsyt.2022.882358.

Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder.

Tso I, Burton C, Lasagna C, Rutherford S, Yao B, Peltier S Psychiatry Res Neuroimaging. 2021; 315:111340.

PMID: 34358977 PMC: 8387449. DOI: 10.1016/j.pscychresns.2021.111340.

Time to Face Language: Embodied Mechanisms Underpin the Inception of Face-Related Meanings in the Human Brain.

Garcia A, Hesse E, Birba A, Adolfi F, Mikulan E, Martorell Caro M Cereb Cortex. 2020; 30(11):6051-6068.

PMID: 32577713 PMC: 7673477. DOI: 10.1093/cercor/bhaa178.

References

Liu Z, He B . fMRI-EEG integrated cortical source imaging by use of time-variant spatial constraints. Neuroimage. 2007; 39(3):1198-214. PMC: 2291020. DOI: 10.1016/j.neuroimage.2007.10.003. View

Nahum L, Gabriel D, Spinelli L, Momjian S, Seeck M, Michel C . Rapid consolidation and the human hippocampus: intracranial recordings confirm surface EEG. Hippocampus. 2010; 21(7):689-93. DOI: 10.1002/hipo.20819. View

Degabriele R, Lagopoulos J, Malhi G . Neural correlates of emotional face processing in bipolar disorder: an event-related potential study. J Affect Disord. 2011; 133(1-2):212-20. DOI: 10.1016/j.jad.2011.03.033. View

Plomp G, Michel C, Herzog M . Electrical source dynamics in three functional localizer paradigms. Neuroimage. 2010; 53(1):257-67. DOI: 10.1016/j.neuroimage.2010.06.037. View

Pavuluri M, Passarotti A, Harral E, Sweeney J . Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder. J Clin Psychiatry. 2010; 71(11):1526-34. PMC: 2994986. DOI: 10.4088/JCP.09m05504yel. View

Favre P, Polosan M, Pichat C, Bougerol T, Baciu M . Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study. PLoS One. 2015; 10(8):e0134961. PMC: 4526683. DOI: 10.1371/journal.pone.0134961. View

Brunet D, Murray M, Michel C . Spatiotemporal analysis of multichannel EEG: CARTOOL. Comput Intell Neurosci. 2011; 2011:813870. PMC: 3022183. DOI: 10.1155/2011/813870. View

Birot G, Spinelli L, Vulliemoz S, Megevand P, Brunet D, Seeck M . Head model and electrical source imaging: a study of 38 epileptic patients. Neuroimage Clin. 2014; 5:77-83. PMC: 4081973. DOI: 10.1016/j.nicl.2014.06.005. View

Kim E, Ku J, Kim J, Lee H, Han K, Kim S . Nonverbal social behaviors of patients with bipolar mania during interactions with virtual humans. J Nerv Ment Dis. 2009; 197(6):412-8. DOI: 10.1097/NMD.0b013e3181a61c3d. View

10.

Farroni T, Csibra G, Simion F, Johnson M . Eye contact detection in humans from birth. Proc Natl Acad Sci U S A. 2002; 99(14):9602-5. PMC: 123187. DOI: 10.1073/pnas.152159999. View

11.

Lascano A, Perneger T, Vulliemoz S, Spinelli L, Garibotto V, Korff C . Yield of MRI, high-density electric source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates. Clin Neurophysiol. 2015; 127(1):150-155. DOI: 10.1016/j.clinph.2015.03.025. View

12.

Hagen G, Gatherwright J, Lopez B, Polich J . P3a from visual stimuli: task difficulty effects. Int J Psychophysiol. 2005; 59(1):8-14. DOI: 10.1016/j.ijpsycho.2005.08.003. View

13.

Conty L, NDiaye K, Tijus C, George N . When eye creates the contact! ERP evidence for early dissociation between direct and averted gaze motion processing. Neuropsychologia. 2007; 45(13):3024-37. DOI: 10.1016/j.neuropsychologia.2007.05.017. View

14.

Gamer M, Hecht H, Seipp N, Hiller W . Who is looking at me? The cone of gaze widens in social phobia. Cogn Emot. 2011; 25(4):756-64. DOI: 10.1080/02699931.2010.503117. View

15.

Rimmele U, Lobmaier J . Stress increases the feeling of being looked at. Psychoneuroendocrinology. 2011; 37(2):292-8. DOI: 10.1016/j.psyneuen.2011.06.013. View

16.

Schulze L, Renneberg B, Lobmaier J . Gaze perception in social anxiety and social anxiety disorder. Front Hum Neurosci. 2014; 7:872. PMC: 3863960. DOI: 10.3389/fnhum.2013.00872. View

17.

Lehmann D, Skrandies W . Reference-free identification of components of checkerboard-evoked multichannel potential fields. Electroencephalogr Clin Neurophysiol. 1980; 48(6):609-21. DOI: 10.1016/0013-4694(80)90419-8. View

18.

Spinelli L, Andino S, Lantz G, Seeck M, Michel C . Electromagnetic inverse solutions in anatomically constrained spherical head models. Brain Topogr. 2001; 13(2):115-25. DOI: 10.1023/a:1026607118642. View

19.

Ochsner K, Gross J . The cognitive control of emotion. Trends Cogn Sci. 2005; 9(5):242-9. DOI: 10.1016/j.tics.2005.03.010. View

20.

Megevand P, Spinelli L, Genetti M, Brodbeck V, Momjian S, Schaller K . Electric source imaging of interictal activity accurately localises the seizure onset zone. J Neurol Neurosurg Psychiatry. 2013; 85(1):38-43. DOI: 10.1136/jnnp-2013-305515. View