Confocal Laser Feedback Tomography for Skin Cancer Detection

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2017 Oct 3

PMID 28966845

Citations 2

Authors

Alireza Mowla

Benjamin Wensheng Du

Thomas Taimre

Karl Bertling

Stephen Wilson

H Peter Soyer

Aleksandar D Rakic

Affiliations

Soon will be listed here.

Abstract

Tomographic imaging of soft tissue such as skin has a potential role in cancer detection. The penetration of infrared wavelengths makes a confocal approach based on laser feedback interferometry feasible. We present a compact system using a semiconductor laser as both transmitter and receiver. Numerical and physical models based on the known optical properties of keratinocyte cancers were developed. We validated the technique on three phantoms containing macro-structural changes in optical properties. Experimental results were in agreement with numerical simulations and structural changes were evident which would permit discrimination of healthy tissue and tumour. Furthermore, cancer type discrimination was also able to be visualized using this imaging technique.

Citing Articles

Feedback Regimes of LFI Sensors: Experimental Investigations.

Bertling K, Qi X, Taimre T, Lim Y, Rakic A Sensors (Basel). 2022; 22(22).

PMID: 36433597 PMC: 9696093. DOI: 10.3390/s22229001.

Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review.

Rey-Barroso L, Pena-Gutierrez S, Yanez C, Burgos-Fernandez F, Vilaseca M, Royo S Sensors (Basel). 2021; 21(1).

PMID: 33401739 PMC: 7795742. DOI: 10.3390/s21010252.

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