The Association Between Genetic Variation in Interleukin-10 Gene and Susceptibility to Henoch-Schönlein Purpura in Chinese Children

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2017 Oct 1

PMID 28963667

Citations 4

Authors

Hui Xu

Guizhen Jiang

Hongqiang Shen

Yanxiang Pan

Junfeng Zhang

Wei Li

Jianhua Mao

Affiliations

Soon will be listed here.

Abstract

Interleukin-10 (IL-10), one of the anti-inflammatory cytokines, plays a major role in the pathogenesis of Henoch-Schönlein purpura (HSP). In present study, we investigated the association between genetic variation in IL-10 gene and susceptibility to HSP in a Chinese childhood population. Considering the overlapping clinical manifestations during the course of disease, the relation between IL-10 gene polymorphisms and HSP clinical heterogeneity was also assessed. We analyzed three IL-10 tag single nucleotide polymorphisms (SNPs; rs3021094, rs3790622, and rs1800872) using the Sequenom MassARRAY system by means of matrix-assisted laser desorption ionization-time of flight mass spectrometry method in 182 patients with HSP and 202 healthy controls. For the frequency of alleles, genotypes, and haplotypes of IL-10 SNPs, no significant differences were observed between HSP patients and controls. In addition, we did not find any association of IL-10 gene polymorphisms with the clinical manifestations of HSP. Our results suggest that genetic variation in IL-10 gene is unlikely to confer susceptibility to HSP in Chinese children.

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References

Eleftheriou D, Brogan P . Vasculitis in children. Best Pract Res Clin Rheumatol. 2009; 23(3):309-23. PMC: 7106032. DOI: 10.1016/j.berh.2009.02.001. View

Gao J, Wei L, Fu R, Wei J, Niu D, Wang L . Association of Interleukin-10 Polymorphisms (rs1800872, rs1800871, and rs1800896) with Predisposition to IgA Nephropathy in a Chinese Han Population: A Case-Control Study. Kidney Blood Press Res. 2017; 42(1):89-98. DOI: 10.1159/000471899. View

Li Y, Li C, Wang G, Yang J, Zu Y . Investigation of the change in CD4⁺ T cell subset in children with Henoch-Schonlein purpura. Rheumatol Int. 2011; 32(12):3785-92. DOI: 10.1007/s00296-011-2266-3. View

Basu P, Chandna P, Bamezai R, Siddiqi M, Saranath D, Lear A . MassARRAY spectrometry is more sensitive than PreTect HPV-Proofer and consensus PCR for type-specific detection of high-risk oncogenic human papillomavirus genotypes in cervical cancer. J Clin Microbiol. 2011; 49(10):3537-44. PMC: 3187302. DOI: 10.1128/JCM.00354-11. View

Lopez-Mejias R, Genre F, Remuzgo-Martinez S, Sevilla Perez B, Castaneda S, Llorca J . Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura. Clin Exp Rheumatol. 2016; 34(3 Suppl 97):S84-8. View

Lin Y, Lan Y, Lai C, Lin T, Huang S, Liao C . Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms. J Clin Lab Anal. 2014; 28(6):461-4. PMC: 6807467. DOI: 10.1002/jcla.21710. View

Sano H, Izumida M, Shimizu H, Ogawa Y . Risk factors of renal involvement and significant proteinuria in Henoch-Schönlein purpura. Eur J Pediatr. 2002; 161(4):196-201. DOI: 10.1007/s00431-002-0922-z. View

Xu H, Pan Y, Li W, Fu H, Zhang J, Shen H . Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. Rheumatol Int. 2016; 36(6):829-35. DOI: 10.1007/s00296-016-3465-8. View

Bantis C, Heering P, Aker S, Klein-Vehne N, Grabensee B, Ivens K . Association of interleukin-10 gene G-1082A polymorphism with the progression of primary glomerulonephritis. Kidney Int. 2004; 66(1):288-94. DOI: 10.1111/j.1523-1755.2004.00730.x. View

10.

Mao Y, Yin L, Xia H, Huang H, Zhou Z, Chen T . Incidence and clinical features of paediatric vasculitis in Eastern China: 14-year retrospective study, 1999-2013. J Int Med Res. 2016; 44(3):710-7. PMC: 5536695. DOI: 10.1177/0300060515621446. View

11.

de Waal Malefyt R, Haanen J, Spits H, Roncarolo M, Te Velde A, Figdor C . Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 1991; 174(4):915-24. PMC: 2118975. DOI: 10.1084/jem.174.4.915. View

12.

Davin J, ten Berge I, Weening J . What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?. Kidney Int. 2001; 59(3):823-34. DOI: 10.1046/j.1523-1755.2001.059003823.x. View

13.

Saulsbury F . Clinical update: Henoch-Schönlein purpura. Lancet. 2007; 369(9566):976-8. DOI: 10.1016/S0140-6736(07)60474-7. View

14.

Hu X, Tai J, Qu Z, Zhao S, Zhang L, Li M . A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. PLoS One. 2016; 11(3):e0152368. PMC: 4816555. DOI: 10.1371/journal.pone.0152368. View

15.

Davin J, Coppo R . Henoch-Schönlein purpura nephritis in children. Nat Rev Nephrol. 2014; 10(10):563-73. DOI: 10.1038/nrneph.2014.126. View

16.

Lopez-Mejias R, Genre F, Remuzgo-Martinez S, Sevilla Perez B, Castaneda S, Llorca J . Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis). Arthritis Res Ther. 2015; 17:286. PMC: 4603645. DOI: 10.1186/s13075-015-0796-x. View

17.

Palafox-Sanchez C, Oregon-Romero E, Salazar-Camarena D, Valle Y, Machado-Contreras J, Cruz A . Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus. Clin Exp Med. 2014; 15(4):439-46. DOI: 10.1007/s10238-014-0315-4. View

18.

Hu J, Hou S, Zhu X, Fang J, Zhou Y, Liu Y . Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. Mol Vis. 2015; 21:589-603. PMC: 4443582. View

19.

Baris S, Akyurek O, Dursun A, Akyol M . The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype. Med Clin (Barc). 2015; 146(9):379-83. DOI: 10.1016/j.medcli.2015.09.017. View

20.

Jen H, Chuang Y, Lin S, Chiang B, Yang Y . Increased serum interleukin-17 and peripheral Th17 cells in children with acute Henoch-Schönlein purpura. Pediatr Allergy Immunol. 2011; 22(8):862-8. DOI: 10.1111/j.1399-3038.2011.01198.x. View