Temporal Development of Near-native Functional Properties and Correlations with QMRI in Self-assembling Fibrocartilage Treated with Exogenous Lysyl Oxidase Homolog 2

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2017 Oct 1

PMID 28963018

Citations 4

Authors

Pasha Hadidi

Derek D Cissell

Jerry C Hu

Kyriacos A Athanasiou

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: This is the first study to demonstrate near-native cross-link content in an engineered tissue, and the first study to quantify pyridinoline cross-link development over time in a self-assembling tissue. Additionally, this work shows the relative contributions of collagen and pyridinoline to the tensile properties of collagenous tissue for the first time. Furthermore, this is the first investigation to identify a relationship between qMRI metrics and the pyridinoline cross-link content of an engineered collagenous tissue.

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