Oxidative Stress and Inflammation As Central Mediators of Atrial Fibrillation in Obesity and Diabetes

Overview

Journal Cardiovasc Diabetol

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
Endocrinology

Date 2017 Oct 1

PMID 28962617

Citations 211

Authors

Basil S Karam

Alejandro Chavez-Moreno

Wonjoon Koh

Joseph G Akar

Fadi G Akar

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.

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