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New Aspects of Vascular Calcification: Histone Deacetylases and Beyond

Overview
Specialty General Medicine
Date 2017 Sep 30
PMID 28960024
Citations 14
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Abstract

Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically deposited in the arteries. Previously, calcification was considered to be a passive process in response to metabolic diseases, vascular or valvular diseases, or even aging. However, now calcification is recognized as a highly-regulated consequence, like bone formation, and many clinical trials have been carried out to elucidate the correlation between vascular calcification and cardiovascular events and mortality. As a result, vascular calcification has been implicated as an independent risk factor in cardiovascular diseases. Many molecules are now known to be actively associated with this process. Recently, our laboratory found that posttranslational modification of histone deacetylase (HDAC) 1 is actively involved in the development of vascular calcification. In addition, we found that modulation of the activity of HDAC as well as its protein stability by MDM2, an HDAC1-E3 ligase, may be a therapeutic target in vascular calcification. In the present review, we overview the pathomechanism of vascular calcification and the involvement of posttranslational modification of epigenetic regulators.

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References
1.
Hruska K, Mathew S, Saab G . Bone morphogenetic proteins in vascular calcification. Circ Res. 2005; 97(2):105-14. DOI: 10.1161/01.RES.00000175571.53833.6c. View

2.
Vattikuti R, Towler D . Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab. 2004; 286(5):E686-96. DOI: 10.1152/ajpendo.00552.2003. View

3.
Choi J, Nam K, Kim J, Baek M, Park J, Park H . Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2005; 25(11):2404-9. DOI: 10.1161/01.ATV.0000184758.07257.88. View

4.
Thompson B, Towler D . Arterial calcification and bone physiology: role of the bone-vascular axis. Nat Rev Endocrinol. 2012; 8(9):529-43. PMC: 3423589. DOI: 10.1038/nrendo.2012.36. View

5.
Oliner J, Kinzler K, Meltzer P, GEORGE D, Vogelstein B . Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992; 358(6381):80-3. DOI: 10.1038/358080a0. View