Depsidones Inhibit Aromatase Activity and Tumor Cell Proliferation in a Co-culture of Human Primary Breast Adipose Fibroblasts and T47D Breast Tumor Cells

Overview

Journal Toxicol Rep

Date 2017 Sep 30

PMID 28959637

Citations 4

Authors

Suthat Chottanapund

M B M van Duursen

Anne Zwartsen

Supatchaya Timtavorn

Panida Navasumrit

Prasat Kittakoop

Sanya Sureram

Mathuros Ruchirawat

Martin van den Berg

Affiliations

Soon will be listed here.

Abstract

Naturally occurring depsidones from the marine fungus are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common depsidones, unguinol and aspergillusidone A, in a co-culture system of human primary breast adipose fibroblasts and hormonal responsive T47D breast tumor cells. Using this model it was shown that these depsidones inhibit the growth of T47D tumor cells most likely via inhibition of aromatase (CYP19) activity. The IC values of these depisidones were compared with the aromatase inhibitors letrozole and exemestane. Letrozole and exemestane had IC values of respectively, 0.19 and 0.14 μM, while those for Unguinol and Aspergillusidone A were respectively, 9.7 and 7.3 μM. Our results indicate that among the depsidones there maybe aromatase inhibitors with possible pharmacotherapeutical relevance.

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