Clinical Efficacy of a New, Enhanced-potency, Inactivated Poliovirus Vaccine

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1988 Apr 23

PMID 2895828

Citations 13

Authors

S E Robertson

H P Traverso

J A Drucker

E Z Rovira

B Fabre-Teste

A Sow

M Ndiaye

M T Sy

F Diouf

Affiliations

Soon will be listed here.

Abstract

The 1986-87 outbreak of paralytic poliomyelitis in Senegal, with 676 reported cases, provided an opportunity to evaluate the efficacy of an enhanced-potency inactivated poliovirus vaccine (N-IPV) in the Kolda region, where this vaccine has been used since 1980. 89 cases, confirmed to have poliomyelitis with residual paralysis, were enrolled in a case-control study, up to 5 matched controls being obtained for each case. The clinical efficacy for one dose of N-IPV was 36% (95% confidence interval 0%, 67%) and for two doses was 89% (95% CI 62%, 97%).

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