A B-cell Line Having Chromosome 14 Aberration at Break Band Q11 Derived from an Adult T-cell Leukemia Patient

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1988 Jan 1

PMID 2895757

Authors

K Miyamoto

M Matsuoka

N Tomita

C Suzuki

Y Sato

A Ishii

K Kitajima

H Nonaka

T Kondo

Y Hiraki

Affiliations

Soon will be listed here.

Abstract

A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from peripheral blood leukocytes of an adult T-cell leukemia (ATL) patient. The same chromosome 14 aberration at break band q11 and chromosome 3 aberration at break band p25 were also found in fresh T-cell leukemia cells. The B-cell line is surface immunoglobulin (sIg)+, immunoglobulin gene rearrangement+, ATL-specific antigen (ATLA)+, HTLV-1 proviral genome+, Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)+ and the EBV DNA genome+. The fresh T-leukemic cells were T-cell receptor gene rearrangement+, the HTLV-1 proviral genome+ and EBV DNA genome.

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