Vascular Stem/progenitor Cells: Functions and Signaling Pathways

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Sep 29

PMID 28956069

Citations 16

Authors

Weisi Lu

Xuri Li

Affiliations

Soon will be listed here.

Abstract

Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical roles in the development, normal physiology, and pathophysiology of numerous diseases. There are four major types of VSCs, including endothelial progenitor cells (EPCs), smooth muscle progenitor cells (SMPCs), pericytes, and mesenchymal stem cells (MSCs). VSCs can be found in bone marrow, circulating blood, vessel walls, and other extravascular tissues. During the past two decades, considerable progress has been achieved in the understanding of the derivation, surface markers, and differentiation of VSCs. Yet, the mechanisms regulating their functions and maintenance under normal and pathological conditions, such as in eye diseases, remain to be further elucidated. Owing to the essential roles of blood vessels in human tissues and organs, understanding the functional properties and the underlying molecular basis of VSCs is of critical importance for both basic and translational research.

Citing Articles

Effects of norepinephrine‑induced activation of rat vascular adventitial fibroblasts on proliferation and migration of BMSCs involved in vascular remodeling.

Gao J, Li L, Zhou D, Sun X, Cui L, Yang D Exp Ther Med. 2023; 25(6):290.

PMID: 37206559 PMC: 10189611. DOI: 10.3892/etm.2023.11989.

Vascular Progenitor Cells: From Cancer to Tissue Repair.

Barachini S, Ghelardoni S, Madonna R J Clin Med. 2023; 12(6).

PMID: 36983398 PMC: 10059009. DOI: 10.3390/jcm12062399.

The Characteristics and Survival Potential Under Sub-lethal Stress of Mesenchymal Stromal/Stem Cells Isolated from the Human Vascular Wall.

Ciavarella C, Valente S, Pasquinelli G Stem Cells. 2022; 40(12):1071-1077.

PMID: 36099050 PMC: 9806765. DOI: 10.1093/stmcls/sxac066.

Emerging roles of mesenchymal stem cell therapy in patients with critical limb ischemia.

Shirbaghaee Z, Hassani M, Heidari Keshel S, Soleimani M Stem Cell Res Ther. 2022; 13(1):462.

PMID: 36068595 PMC: 9449296. DOI: 10.1186/s13287-022-03148-9.

A histological study of vascular wall resident stem cells in venous malformations.

Xia H, Lai W, Chen G, Li Y, Xie Q, Jia Y Cell Tissue Res. 2022; 390(2):229-243.

PMID: 35916917 DOI: 10.1007/s00441-022-03672-3.

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