Noncanonical Wnt Signaling in Stromal Cells Regulates B-lymphogenesis Through Interleukin-7 Expression

Overview

Journal Biochem Biophys Rep

Specialty Biochemistry

Date 2017 Sep 29

PMID 28955876

Citations 1

Authors

Mari Sato

Masato Tamura

Affiliations

Soon will be listed here.

Abstract

The regulation of early B cell development and the interaction of hematopoietic precursors with stromal cells in the bone marrow (BM) are controlled by various secreted signaling molecules. Several recent studies showed Wnt signaling involved in B-lymphogenesis through stromal cells. However, the molecules modulated by Wnt signaling in stromal cells regulating B-lymphogenesis have not been identified yet. Interleukin (IL)-7 and CXC chemokine ligand (CXCL) 12 are known to be express in stromal cells, and both molecules are essential for B-lymphogenesis. In the present study, we examined the role of Wnt signaling in regulating IL-7 and CXCL12 expression and in affecting B-lymphogenesis. In mouse stromal ST2 cells, expression of IL-7 and CXCL12 mRNA was augmented by noncanonical Wnt5a. When mouse BM-derived cells were cultured on Wnt5a-overexpressing ST2 cells, an increased number of B220+/IgM- B-lymphoid precursor cells was observed. These results show that Wnt5a regulates IL-7 gene expression in stromal cells and suggest the possibility that noncanonical Wnt regulates B-lymphogenesis via IL-7 expression in stromal cells.

Citing Articles

Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection.

Muller U, Schaub G, Mossmann H, Kohler G, Carsetti R, Holscher C Front Immunol. 2019; 9:2794.

PMID: 30619242 PMC: 6295583. DOI: 10.3389/fimmu.2018.02794.

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