Drosophila GSTs Display Outstanding Catalytic Efficiencies with the Environmental Pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene

Overview

Journal Biochem Biophys Rep

Specialty Biochemistry

Date 2017 Sep 29

PMID 28955816

Citations 2

Authors

Aslam M A Mazari

Bengt Mannervik

Affiliations

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Abstract

The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) are toxic environmental pollutants. The biotransformation and detoxication of these persistent compounds in higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathione transferases (GSTs) and GSTs from the fruit fly are catalysts of the biotransformation of TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, GSTE6 and GSTE7 displayed outstanding high activities with both substrates.

Citing Articles

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