Molecular Basis of Basal Cell Carcinoma

Overview

Journal An Bras Dermatol

Specialty Dermatology

Date 2017 Sep 28

PMID 28954101

Citations 8

Authors

Erik Montagna

Otavio Sergio Lopes

Affiliations

Soon will be listed here.

Abstract

Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, Fitzpatrick classification), family history of basal cell carcinoma (30-60%), freckles in childhood, eyes and light hair. The environmental risk factor better established is exposure to ultraviolet radiation. However, different solar exposure scenarios probably are independent risk factors for certain clinical and histological types, topographies and prognosis of this tumor, and focus of controversy among researchers. Studies confirm that changes in cellular genes Hedgehog signaling pathway are associated with the development of basal cell carcinoma. The cellular Hedgehog signaling pathway is activated in organogenesis, but is altered in various types of tumors.

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References

Dreier J, Dummer R, Felderer L, Nageli M, Gobbi S, Kunstfeld R . Emerging drugs and combination strategies for basal cell carcinoma. Expert Opin Emerg Drugs. 2014; 19(3):353-65. DOI: 10.1517/14728214.2014.914171. View

Ruiz Lascano A, Kuznitzky R, Garay I, Ducasse C, Albertini R . [Risk factors for basal cell carcinoma. Case-control study in Cordoba]. Medicina (B Aires). 2006; 65(6):495-500. View

Liang M, Lv J, Chu H, Wang J, Chen X, Zhu X . Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity. J Dermatol Sci. 2014; 76(2):104-11. DOI: 10.1016/j.jdermsci.2014.08.002. View

Hahn H, Wicking C, Zaphiropoulous P, Gailani M, Shanley S, Chidambaram A . Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996; 85(6):841-51. DOI: 10.1016/s0092-8674(00)81268-4. View

Donovan J . Review of the hair follicle origin hypothesis for basal cell carcinoma. Dermatol Surg. 2009; 35(9):1311-23. DOI: 10.1111/j.1524-4725.2009.01236.x. View

Roewert-Huber J, Lange-Asschenfeldt B, Stockfleth E, Kerl H . Epidemiology and aetiology of basal cell carcinoma. Br J Dermatol. 2007; 157 Suppl 2:47-51. DOI: 10.1111/j.1365-2133.2007.08273.x. View

Chinem V, Miot H . Epidemiology of basal cell carcinoma. An Bras Dermatol. 2011; 86(2):292-305. DOI: 10.1590/s0365-05962011000200013. View

Hooper J, Scott M . Communicating with Hedgehogs. Nat Rev Mol Cell Biol. 2005; 6(4):306-17. DOI: 10.1038/nrm1622. View

RIPPEY J . Why classify basal cell carcinomas?. Histopathology. 1998; 32(5):393-8. DOI: 10.1046/j.1365-2559.1998.00431.x. View

10.

Madan V, Hoban P, Strange R, Fryer A, Lear J . Genetics and risk factors for basal cell carcinoma. Br J Dermatol. 2006; 154 Suppl 1:5-7. DOI: 10.1111/j.1365-2133.2006.07229.x. View

11.

Bernard P, Dupuy A, Sasco A, Brun P, Duru G, Nicoloyannis N . Basal cell carcinomas and actinic keratoses seen in dermatological practice in France: a cross-sectional survey. Dermatology. 2008; 216(3):194-9. DOI: 10.1159/000112925. View

12.

Rubin A, Chen E, Ratner D . Basal-cell carcinoma. N Engl J Med. 2005; 353(21):2262-9. DOI: 10.1056/NEJMra044151. View

13.

Chiang C, Litingtung Y, Lee E, Young K, Corden J, Westphal H . Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996; 383(6599):407-13. DOI: 10.1038/383407a0. View

14.

Hoban P, Ramachandran S, Strange R . Environment, phenotype and genetics: risk factors associated with BCC of the skin. Expert Rev Anticancer Ther. 2002; 2(5):570-9. DOI: 10.1586/14737140.2.5.570. View

15.

Berman D, Karhadkar S, Maitra A, Montes de Oca R, Gerstenblith M, Briggs K . Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003; 425(6960):846-51. DOI: 10.1038/nature01972. View

16.

Madras J, Lapointe H . Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J Can Dent Assoc. 2008; 74(2):165-165h. View

17.

Ma X, Chen K, Huang S, Zhang X, Adegboyega P, Evers B . Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005; 26(10):1698-705. DOI: 10.1093/carcin/bgi130. View

18.

Nusslein-Volhard C, Wieschaus E . Mutations affecting segment number and polarity in Drosophila. Nature. 1980; 287(5785):795-801. DOI: 10.1038/287795a0. View

19.

Heretsch P, Tzagkaroulaki L, Giannis A . Modulators of the hedgehog signaling pathway. Bioorg Med Chem. 2010; 18(18):6613-24. DOI: 10.1016/j.bmc.2010.07.038. View

20.

Armstrong B, Kricker A . The epidemiology of UV induced skin cancer. J Photochem Photobiol B. 2001; 63(1-3):8-18. DOI: 10.1016/s1011-1344(01)00198-1. View