Sulphasalazine in Arthritis--an Old Drug Rediscovered

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 1987 Sep 1

PMID 2894913

Citations 2

Authors

A J Taggart

Affiliations

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Abstract

Sulphasalazine (salicyl-azo-sulphapyridine) has been in clinical use for over 40 years. Although the drug was originally introduced for the treatment of 'rheumatic polyarthritis' and ulcerative colitis, it is only in the past 10 years that its value in rheumatology has been appreciated. Controlled studies indicate that the drug is an effective remittive agent in both rheumatoid arthritis and ankylosing spondylitis. This is an area of great research interest since the drug is proving to be a useful tool for investigating the aeteology and pathogenesis of these diseases.

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References

Azad Khan A, Piris J, TRUELOVE S . An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet. 1977; 2(8044):892-5. DOI: 10.1016/s0140-6736(77)90831-5. View

Dew M, Hughes P, Harries A, Williams G, Evans B, Rhodes J . Maintenance of remission in ulcerative colitis with oral preparation of 5-aminosalicylic acid. Br Med J (Clin Res Ed). 1982; 285(6347):1012. PMC: 1500334. DOI: 10.1136/bmj.285.6347.1012. View

Taggart A, McDermott B, Delargy M, Elborn S, Forbes J, Roberts S . The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis. Scand J Rheumatol Suppl. 1987; 64:29-36. DOI: 10.3109/03009748709096719. View

Crisp A . Sulphasalazine in rheumatoid arthritis. Br J Rheumatol. 1984; 23(3):232. DOI: 10.1093/rheumatology/23.3.232-a. View

Van de Pette J, Cunnah D, Shallcross T . Bone marrow necrosis after treatment with sulphasalazine. Br Med J (Clin Res Ed). 1984; 289(6448):798. PMC: 1442906. DOI: 10.1136/bmj.289.6448.798. View

Pullar T, Hunter J, Capell H . Sulphasalazine in rheumatoid arthritis: a double blind comparison of sulphasalazine with placebo and sodium aurothiomalate. Br Med J (Clin Res Ed). 1983; 287(6399):1102-4. PMC: 1549364. DOI: 10.1136/bmj.287.6399.1102. View

Pullar T, Hunter J, Capell H . Which component of sulphasalazine is active in rheumatoid arthritis?. Br Med J (Clin Res Ed). 1985; 290(6481):1535-8. PMC: 1415752. DOI: 10.1136/bmj.290.6481.1535. View

Grindulis K, MCCONKEY B . Does sulphasalazine cause folate deficiency in rheumatoid arthritis?. Scand J Rheumatol. 1985; 14(3):265-70. DOI: 10.3109/03009748509100404. View

MCCONKEY B, Davies P, Crockson R, Crockson A, Butler M, Constable T . Dapsone in rheumatoid arthritis. Rheumatol Rehabil. 1976; 15(3):230-4. DOI: 10.1093/rheumatology/15.3.230. View

10.

Thomas P, Seaton A, Edwards J . Respiratory disease due to sulphasalazine. Clin Allergy. 1974; 4(1):41-7. DOI: 10.1111/j.1365-2222.1974.tb01361.x. View

11.

Farr M, Symmons D, Bacon P . Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid patients treated with sulphasalazine. Ann Rheum Dis. 1985; 44(11):798-800. PMC: 1001781. DOI: 10.1136/ard.44.11.798. View

12.

Mielants H, Veys E . Inflammation of the ileum in patients with B27-positive reactive arthritis. Lancet. 1984; 1(8371):288. DOI: 10.1016/s0140-6736(84)90163-6. View

13.

Das K, Eastwood M, MCMANUS J, Sircus W . Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype. N Engl J Med. 1973; 289(10):491-5. DOI: 10.1056/NEJM197309062891001. View

14.

WRIGHT V . Treatment of severe rheumatoid arthritis. Br Med J (Clin Res Ed). 1986; 292(6518):431-2. PMC: 1339418. DOI: 10.1136/bmj.292.6518.431. View

15.

Klotz U . Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid. Clin Pharmacokinet. 1985; 10(4):285-302. DOI: 10.2165/00003088-198510040-00001. View

16.

Dougados M, Boumier P, Amor B . Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients. Br Med J (Clin Res Ed). 1986; 293(6552):911-4. PMC: 1341708. DOI: 10.1136/bmj.293.6552.911. View

17.

Neumann V, Taggart A, le Gallez P, Astbury C, Hill J, Bird H . A study to determine the active moiety of sulphasalazine in rheumatoid arthritis. J Rheumatol. 1986; 13(2):285-7. View

18.

Giwercman A, Skakkebaek N . The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review. Int J Androl. 1986; 9(1):38-52. DOI: 10.1111/j.1365-2605.1986.tb00866.x. View

19.

Mielants H, Veys E . HLA-B27 related arthritis and bowel inflammation. Part 1. Sulfasalazine (salazopyrin) in HLA-B27 related reactive arthritis. J Rheumatol. 1985; 12(2):287-93. View

20.

Kuzell W, Gardner G . Salicylazosulfapyridine (salazopyrin or azopyrin) in rheumatoid arthritis and experimental polyarthritis. Calif Med. 1950; 73(6):476-80. PMC: 1520779. View