HTLV-I-associated Leukemia: a Model for Chronic Retroviral Diseases

Overview

Journal Ann Neurol

Specialty Neurology

Date 1988 Jan 1

PMID 2894810

Citations 5

Authors

E L Murphy

W A Blattner

Affiliations

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Abstract

Human T-lymphotropic virus type I (HTLV-I) has been associated with adult T-cell leukemia/lymphoma (ATL), a malignancy of mature CD4-positive lymphocytes, and with tropical spastic paraparesis (TSP), a demyelinating neurological syndrome. This article describes the clinical and pathological features of ATL and reviews the epidemiology of this disease and of its putative etiological agent, HTLV-I. From what is known about the molecular biology and epidemiology of HTLV-I, hypotheses on the etiology of TSP are proposed, and strategies for studying the neurological syndrome are suggested.

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