Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model

Overview

Journal J Am Heart Assoc

Specialty Cardiology & Vascular Diseases

Date 2017 Sep 27

PMID 28947563

Citations 27

Authors

Aleksandra Mas-Stachurska

Anna-Maria Siegert

Monsterrat Batlle

Darya Gorbenko Del Blanco

Thayna Meirelles

Cira Rubies

Fabio Bonorino

Carla Serra-Peinado

Bart Bijnens

Julio Baudin

Marta Sitges

Lluis Mont

Eduard Guasch

Gustavo Egea

Affiliations

Soon will be listed here.

Abstract

Background: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype.

Methods And Results: In a transgenic mouse model of MF (), 4-month-old wild-type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4-month-old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5-month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild-type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis.

Conclusions: Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype.

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