Whole Grains in Amelioration of Metabolic Derangements

Overview

Journal J Nutrit Health Food Sci

Publisher Symbiosis Group

Date 2017 Sep 26

PMID 28944285

Citations 7

Authors

Samir Develaraja

Anup Reddy

Mukesh Yadav

Shalini Jain

Hariom Yadav

Affiliations

Soon will be listed here.

Abstract

Daily diet influences whole body metabolism, and intricately linked to the prevention or progression of metabolic diseases including obesity, diabetes and cardiovascular diseases. Several epidemiological and large scale studies have shown that diets enriched with whole grains improves metabolic function and protect from the development of metabolic diseases. Direct impact of whole grain diet can be mediated on several levels of metabolic functions i.e. reduced glycemic index, improved fat oxidation potential, increased cholesterol clearance or decreased cholesterol biosynthesis and modulation of gut microbiome. In this article we reviewed several studies indicating the beneficial effects of whole grain diets on metabolic functions, as well as discussed the potential active phytochemicals present in these whole grain foods to contribute in modulation of metabolic function in our body.

Citing Articles

Effect of Germination on Fatty Acid Composition in Cereal Grains.

Al-Taher F, Nemzer B Foods. 2023; 12(17).

PMID: 37685238 PMC: 10487171. DOI: 10.3390/foods12173306.

Gender-specific effects of soybean consumption on cardiovascular events in elderly individuals from rural Northeast China - a prospective cohort study.

Yu S, Yang H, Wang B, Guo X, Li G, Sun Y BMC Geriatr. 2023; 23(1):510.

PMID: 37612640 PMC: 10464065. DOI: 10.1186/s12877-023-04209-1.

Analysis of Fatty Acid Composition in Sprouted Grains.

Nemzer B, Al-Taher F Foods. 2023; 12(9).

PMID: 37174393 PMC: 10178583. DOI: 10.3390/foods12091853.

Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study.

Swaminathan S, Dehghan M, Raj J, Thomas T, Rangarajan S, Jenkins D BMJ. 2021; 372:m4948.

PMID: 33536317 PMC: 7856570. DOI: 10.1136/bmj.m4948.

Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth ( Mart. ex Thell.) on Sprague Dawley Rats.

Sanchez-Urdaneta A, Montero-Quintero K, Gonzalez-Redondo P, Molina E, Bracho-Bravo B, Moreno-Rojas R Foods. 2020; 9(6).

PMID: 32492837 PMC: 7353626. DOI: 10.3390/foods9060707.

References

Dilworth L, Omoruyi F, Simon O, Morrison E, Asemota H . The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism. West Indian Med J. 2005; 54(2):102-6. DOI: 10.1590/s0043-31442005000200003. View

Dekker M, Verkerk R, van der Sluis A, Khokhar S, Jongen W . Analysing the antioxidant activity of food products: processing and matrix effects. Toxicol In Vitro. 2010; 13(4-5):797-9. DOI: 10.1016/s0887-2333(99)00057-0. View

Connolly M, Lovegrove J, Tuohy K . In vitro evaluation of the microbiota modulation abilities of different sized whole oat grain flakes. Anaerobe. 2010; 16(5):483-8. DOI: 10.1016/j.anaerobe.2010.07.001. View

Foerster J, Maskarinec G, Reichardt N, Tett A, Narbad A, Blaut M . The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PLoS One. 2014; 9(10):e109606. PMC: 4192132. DOI: 10.1371/journal.pone.0109606. View

Zhou A, Hergert N, Rompato G, Lefevre M . Whole grain oats improve insulin sensitivity and plasma cholesterol profile and modify gut microbiota composition in C57BL/6J mice. J Nutr. 2015; 145(2):222-30. DOI: 10.3945/jn.114.199778. View

Hasan M, Alshuaib W, Singh S, Fahim M . Effects of alpha-tocopherol on diabetes-induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle. Endocr Res. 2003; 29(4):419-28. DOI: 10.1081/erc-120026948. View

Juntunen K, Niskanen L, Liukkonen K, Poutanen K, Holst J, Mykkanen H . Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects. Am J Clin Nutr. 2002; 75(2):254-62. DOI: 10.1093/ajcn/75.2.254. View

Adom K, Liu R . Antioxidant activity of grains. J Agric Food Chem. 2002; 50(21):6182-7. DOI: 10.1021/jf0205099. View

Li C, Zhang W, Frei B . Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction. Redox Biol. 2016; 9:104-113. PMC: 4961307. DOI: 10.1016/j.redox.2016.06.006. View

10.

Holst B, Williamson G . Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Curr Opin Biotechnol. 2008; 19(2):73-82. DOI: 10.1016/j.copbio.2008.03.003. View

11.

Sies H . Carotenoids and tocopherols as antioxidants and singlet oxygen quenchers. J Nutr Sci Vitaminol (Tokyo). 1992; Spec No:27-33. DOI: 10.3177/jnsv.38.special_27. View

12.

Rasane P, Jha A, Kumar A, Sharma N . Reduction in phytic acid content and enhancement of antioxidant properties of nutricereals by processing for developing a fermented baby food. J Food Sci Technol. 2015; 52(6):3219-34. PMC: 4444874. DOI: 10.1007/s13197-014-1375-x. View

13.

Muka T, Kraja B, Ruiter R, de Keyser C, Hofman A, Stricker B . Dietary polyunsaturated fatty acids intake modifies the positive association between serum total cholesterol and colorectal cancer risk: the Rotterdam Study. J Epidemiol Community Health. 2016; 70(9):881-7. DOI: 10.1136/jech-2015-206556. View

14.

Sze M, Schloss P . Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome. mBio. 2016; 7(4). PMC: 4999546. DOI: 10.1128/mBio.01018-16. View

15.

Davis T, Weerarathne T, Foong Y, Mason C, Davis W . Community-acquired infections in type 2 diabetic patients and their nondiabetic partners. The Fremantle Diabetes Study. J Diabetes Complications. 2005; 19(5):259-63. DOI: 10.1016/j.jdiacomp.2005.03.003. View

16.

Schroeder N, Gallaher D, Arndt E, Marquart L . Influence of whole grain barley, whole grain wheat, and refined rice-based foods on short-term satiety and energy intake. Appetite. 2009; 53(3):363-9. DOI: 10.1016/j.appet.2009.07.019. View

17.

Liu S, Manson J, Stampfer M, Hu F, Giovannucci E, Colditz G . A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women. Am J Public Health. 2000; 90(9):1409-15. PMC: 1447620. DOI: 10.2105/ajph.90.9.1409. View

18.

Kunyanga C, Imungi J, Okoth M, Biesalski H, Vadivel V . Antioxidant and type 2 diabetes related functional properties of phytic acid extract from Kenyan local food ingredients: effects of traditional processing methods. Ecol Food Nutr. 2011; 50(5):452-71. DOI: 10.1080/03670244.2011.604588. View

19.

Zielinski H, Kozlowska H . Antioxidant activity and total phenolics in selected cereal grains and their different morphological fractions. J Agric Food Chem. 2000; 48(6):2008-16. DOI: 10.1021/jf990619o. View

20.

Harnack L, Walters S, Jacobs Jr D . Dietary intake and food sources of whole grains among US children and adolescents: data from the 1994-1996 Continuing Survey of Food Intakes by Individuals. J Am Diet Assoc. 2003; 103(8):1015-9. DOI: 10.1016/s0002-8223(03)00470-x. View