Low Expression of MicroRNA-1908 Predicts a Poor Prognosis for Patients with Ovarian Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Sep 26

PMID 28943939

Citations 21

Authors

Changcai Teng

Hong Zheng

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRs) serve important roles in cancer genesis and progression. The expression of miR-1908 has been reported in a number of types of cancer; however, the clinical significance of miR-1908 in human ovarian cancer (OC) remains unclear. A total of 491 patients with OC from The Cancer Genome Atlas project cohort were selected and divided into two groups according to the median expression level of miR-1908. Univariate and multivariate analyses, using the Kaplan-Meier method and Cox regression, were performed to identify the characteristics that predict OC prognosis. Bioinformatics tools were used to identify potential targets of miR-1908. It was identified that the low expression of miR-1908 is associated with a poor prognosis for OC (P<0.05). The potential target genes of miR-1908 included podocan-like 1, JunB AP-1 transcription factor subunit, homeobox B8, SET binding factor 1 and sirtuin 2; high expression of these five genes additionally predicted a poor prognosis. These results suggest that miR-1908 may be a suitable target for the development of novel approaches in OC diagnosis and therapy in the future.

Citing Articles

A Novel Insight into the Role of Obesity-Related Adipokines in Ovarian Cancer-State-of-the-Art Review and Future Perspectives.

Kolakowska K, Kisluk J, Niklinski J Int J Mol Sci. 2025; 26(5).

PMID: 40076482 PMC: 11900017. DOI: 10.3390/ijms26051857.

Utilization of miRNAs as Biomarkers for the Diagnosis, Prognosis, and Metastasis in Gynecological Malignancies.

Lazaridis A, Katifelis H, Kalampokas E, Lambropoulou D, Aravantinos G, Gazouli M Int J Mol Sci. 2024; 25(21).

PMID: 39519256 PMC: 11546551. DOI: 10.3390/ijms252111703.

JunB: a paradigm for Jun family in immune response and cancer.

Ren F, Cai X, Yao Y, Fang G Front Cell Infect Microbiol. 2023; 13:1222265.

PMID: 37731821 PMC: 10507257. DOI: 10.3389/fcimb.2023.1222265.

Small Leucine-Rich Proteoglycan Identified as a Potential Tumor Matrix-Mediated Biomarker for Prognosis and Immunotherapy in a Pan-Cancer Setting.

Dai G, Sun Y, Wei R, Xi L Curr Issues Mol Biol. 2023; 45(7):6116-6139.

PMID: 37504302 PMC: 10378008. DOI: 10.3390/cimb45070386.

MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway.

Liu W, Ying N, Rao X, Chen X Curr Issues Mol Biol. 2022; 44(9):3835-3848.

PMID: 36135175 PMC: 9498168. DOI: 10.3390/cimb44090263.

References

Corney D, Hwang C, Matoso A, Vogt M, Flesken-Nikitin A, Godwin A . Frequent downregulation of miR-34 family in human ovarian cancers. Clin Cancer Res. 2010; 16(4):1119-28. PMC: 2822884. DOI: 10.1158/1078-0432.CCR-09-2642. View

Rawlings-Goss R, Campbell M, Tishkoff S . Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers. BMC Med Genomics. 2014; 7:53. PMC: 4159108. DOI: 10.1186/1755-8794-7-53. View

Kilic Eren M, Kilincli A, Eren O . Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One. 2015; 10(4):e0124837. PMC: 4414559. DOI: 10.1371/journal.pone.0124837. View

Atsaves V, Lekakis L, Drakos E, Leventaki V, Ghaderi M, Baltatzis G . The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma. Br J Haematol. 2014; 167(4):514-23. DOI: 10.1111/bjh.13079. View

Xie C, Shi K, Zhang X, Zhao J, Yu J . MiR-1908 promotes scar formation post-burn wound healing by suppressing Ski-mediated inflammation and fibroblast proliferation. Cell Tissue Res. 2016; 366(2):371-380. DOI: 10.1007/s00441-016-2434-6. View

Yuan H, Gao Y . MicroRNA-1908 is upregulated in human osteosarcoma and regulates cell proliferation and migration by repressing PTEN expression. Oncol Rep. 2015; 34(5):2706-14. DOI: 10.3892/or.2015.4242. View

Xia X, Li Y, Wang W, Tang F, Tan J, Sun L . MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway. Mol Cancer. 2015; 14:154. PMC: 4534015. DOI: 10.1186/s12943-015-0423-0. View

Ye S, Li Z, Luo D, Huang B, Chen Y, Zhang X . Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014; 5(14):5439-52. PMC: 4170615. DOI: 10.18632/oncotarget.2118. View

Ghanbari M, Sedaghat S, de Looper H, Hofman A, Erkeland S, Franco O . The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose. Obesity (Silver Spring). 2015; 23(2):495-503. DOI: 10.1002/oby.20975. View

10.

Miles G, Seiler M, Rodriguez L, Rajagopal G, Bhanot G . Identifying microRNA/mRNA dysregulations in ovarian cancer. BMC Res Notes. 2012; 5:164. PMC: 3342161. DOI: 10.1186/1756-0500-5-164. View

11.

Zhang B, Cai F, Zhong X . An overview of biomarkers for the ovarian cancer diagnosis. Eur J Obstet Gynecol Reprod Biol. 2011; 158(2):119-23. DOI: 10.1016/j.ejogrb.2011.04.023. View

12.

Gerhard D, Wagner L, Feingold E, Shenmen C, Grouse L, Schuler G . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004; 14(10B):2121-7. PMC: 528928. DOI: 10.1101/gr.2596504. View

13.

Liu G, Xue F, Zhang W . miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis. Chin J Cancer. 2015; 34(11):485-7. PMC: 4593343. DOI: 10.1186/s40880-015-0049-z. View

14.

Shou J, Gu S, Gu W . Identification of dysregulated miRNAs and their regulatory signature in glioma patients using the partial least squares method. Exp Ther Med. 2014; 9(1):167-171. PMC: 4247319. DOI: 10.3892/etm.2014.2041. View

15.

Lian D, Wang Z, Liu N . MicroRNA-1908 is a biomarker for poor prognosis in human osteosarcoma. Eur Rev Med Pharmacol Sci. 2016; 20(7):1258-62. View

16.

Salmanidis M, Brumatti G, Narayan N, Green B, van den Bergen J, Sandow J . Hoxb8 regulates expression of microRNAs to control cell death and differentiation. Cell Death Differ. 2013; 20(10):1370-80. PMC: 3770316. DOI: 10.1038/cdd.2013.92. View

17.

Long C, Jiang L, Wei F, Ma C, Zhou H, Yang S . Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas. PLoS One. 2013; 8(6):e66676. PMC: 3691184. DOI: 10.1371/journal.pone.0066676. View

18.

Kim J, Park C, Um D, Baek K, Jo Y, An H . Mass spectrometric screening of ovarian cancer with serum glycans. Dis Markers. 2014; 2014:634289. PMC: 3932261. DOI: 10.1155/2014/634289. View

19.

Kurat C, Lambert J, Petschnigg J, Friesen H, Pawson T, Rosebrock A . Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation. Proc Natl Acad Sci U S A. 2014; 111(39):14124-9. PMC: 4191790. DOI: 10.1073/pnas.1414024111. View

20.

Grbesa I, Pajares M, Martinez-Terroba E, Agorreta J, Mikecin A, Larrayoz M . Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. PLoS One. 2015; 10(4):e0124670. PMC: 4411155. DOI: 10.1371/journal.pone.0124670. View