Expression of Chicken Ovalbumin Upstream Promoter-transcription Factor II and Liver X Receptor As Prognostic Indicators for Human Colorectal Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2017 Sep 26

PMID 28943908

Citations 6

Authors

Seong-Hoon Yun

Min-Gyoung Park

Yu-Mi Kim

Mee-Sook Roh

Joo-In Park

Affiliations

Soon will be listed here.

Abstract

Cholesterol increases the risk of colorectal cancer. Liver X receptor (LXR), retinoid X receptor (RXR)α and sterol regulatory element binding protein (SREBP)-1c are transcriptional regulators of lipid metabolism. Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) serves an essential role in angiogenesis and development, but its role in cancer is controversial. The expression of COUP-TFII, LXR, RXRα and SREBP-1c in colorectal cancer, as well as their association with clinicopathologic features, was assessed, and their utility as prognostic indicators in colorectal cancer evaluated. Colorectal cancer samples (n=707 patients) were analyzed for COUP-TII, LXR, RXRα and SREBP-1c expression by immunohistochemistry. Overall survival curves of patients with tumors expressing different levels of these proteins were produced and risk factors were assessed. Of the 707 patients, 32.7, 50.9, 56.4, and 41.7% were positive for COUP-TFII, LXR, RXRα, and SREBP-1c, respectively. The lack of COUP-TFII or LXR expression was associated with lower overall survival rates (P=0.0154 for COUP-TFII, and 0.0113 for LXR). Following adjustment for other clinical risk factors (age, sex, tumor size, grade, vascular invasion, and Tumor-Node-Metastasis stage), the lack of COUP-TFII or LXR expression was a negative independent prognostic factor for survival. The expression of COUP-TFII and LXR alone or in combination may be biomarkers to indicate a positive prognosis in patients with colorectal cancer.

Citing Articles

Delineating the role of nuclear receptors in colorectal cancer, a focused review.

Manickasamy M, Jayaprakash S, Girisa S, Kumar A, Lam H, Okina E Discov Oncol. 2024; 15(1):41.

PMID: 38372868 PMC: 10876515. DOI: 10.1007/s12672-023-00808-x.

Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer.

Park S, Cho J, Han S, Kim Y, Pak M, Roh M Biomed Res Int. 2023; 2023:9057735.

PMID: 37096225 PMC: 10122595. DOI: 10.1155/2023/9057735.

Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.

Shao W, Kuhn C, Mayr D, Ditsch N, Kailuwait M, Wolf V J Cancer Res Clin Oncol. 2021; 147(9):2535-2544.

PMID: 34085098 PMC: 8310839. DOI: 10.1007/s00432-021-03670-y.

Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer.

Yun S, Park J J Int Med Res. 2020; 48(4):300060520919236.

PMID: 32338091 PMC: 7218465. DOI: 10.1177/0300060520919236.

COUP-TFII in Health and Disease.

Polvani S, Pepe S, Milani S, Galli A Cells. 2020; 9(1).

PMID: 31906104 PMC: 7016888. DOI: 10.3390/cells9010101.

References

Navab R, Wang Y, Chow Y, Wang A, Jankov R, Takamoto N . Regulation of human Clara cell 10 kD protein expression by chicken ovalbumin upstream promoter transcription factors (COUP-TFs). Am J Respir Cell Mol Biol. 2002; 27(3):273-85. DOI: 10.1165/rcmb.2002-0014OC. View

Jiang S, Shen S, Shyu R, Yu J, Harn H, Yeh M . Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization. Br J Cancer. 1999; 80(1-2):206-14. PMC: 2362992. DOI: 10.1038/sj.bjc.6690340. View

Nagahama H, Minamishima Y, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M . Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000; 19(9):2069-81. PMC: 305685. DOI: 10.1093/emboj/19.9.2069. View

Yang Y, Han W, Morin P, Chrest F, Pizer E . Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res. 2002; 279(1):80-90. DOI: 10.1006/excr.2002.5600. View

Brenner H, Kloor M, Pox C . Colorectal cancer. Lancet. 2013; 383(9927):1490-1502. DOI: 10.1016/S0140-6736(13)61649-9. View

McKenna N, Cooney A, DeMayo F, Downes M, Glass C, Lanz R . Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009; 23(6):740-6. PMC: 2691684. DOI: 10.1210/me.2009-0135. View

Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y . Suppression of beta-catenin signaling by liver X receptor ligands. Biochem Pharmacol. 2008; 77(2):186-95. DOI: 10.1016/j.bcp.2008.10.007. View

Zhang C, Han Y, Huang H, Qu L, Shou C . High NR2F2 transcript level is associated with increased survival and its expression inhibits TGF-β-dependent epithelial-mesenchymal transition in breast cancer. Breast Cancer Res Treat. 2014; 147(2):265-81. DOI: 10.1007/s10549-014-3095-3. View

Shin S, Kwon H, Rho M, Choi H, Kwak J, Park J . Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer. Oncol Rep. 2008; 21(1):101-6. View

10.

Nakshatri H, Mendonca M, Bhat-Nakshatri P, Patel N, Goulet Jr R, Cornetta K . The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2. Biochem Biophys Res Commun. 2000; 270(3):1144-53. DOI: 10.1006/bbrc.2000.2562. View

11.

Sun Y, He W, Luo M, Zhou Y, Chang G, Ren W . SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism. Tumour Biol. 2015; 36(6):4133-41. DOI: 10.1007/s13277-015-3047-5. View

12.

Navab R, Gonzalez-Santos J, Johnston M, Liu J, Brodt P, Tsao M . Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells. Cancer Res. 2004; 64(15):5097-105. DOI: 10.1158/0008-5472.CAN-03-1185. View

13.

Vedin L, Lewandowski S, Parini P, Gustafsson J, Steffensen K . The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis. 2009; 30(4):575-9. DOI: 10.1093/carcin/bgp029. View

14.

Wojcicka G, Jamroz-Wisniewska A, Horoszewicz K, Beltowski J . Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism. Postepy Hig Med Dosw (Online). 2007; 61:736-59. View

15.

Scoles D, Xu X, Wang H, Tran H, Taylor-Harding B, Li A . Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Gynecol Oncol. 2009; 116(1):109-16. DOI: 10.1016/j.ygyno.2009.09.034. View

16.

Bao Y, Gu D, Feng W, Sun X, Wang X, Zhang X . COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1. Br J Cancer. 2014; 111(5):933-43. PMC: 4150277. DOI: 10.1038/bjc.2014.373. View

17.

Mangelsdorf D, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K . The nuclear receptor superfamily: the second decade. Cell. 1995; 83(6):835-9. PMC: 6159888. DOI: 10.1016/0092-8674(95)90199-x. View

18.

Qin J, Tsai S, Tsai M . The critical roles of COUP-TFII in tumor progression and metastasis. Cell Biosci. 2014; 4(1):58. PMC: 4201699. DOI: 10.1186/2045-3701-4-58. View

19.

Yang Y, Morin P, Han W, Chen T, Bornman D, Gabrielson E . Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res. 2003; 282(2):132-7. DOI: 10.1016/s0014-4827(02)00023-x. View

20.

Kumar R, Shoemaker A, Verma A . Retinoic acid nuclear receptors and tumor promotion: decreased expression of retinoic acid nuclear receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis. 1994; 15(4):701-5. DOI: 10.1093/carcin/15.4.701. View