Immunoparalysis in Pediatric Critical Care

Overview

Journal Pediatr Clin North Am

Specialty Pediatrics

Date 2017 Sep 25

PMID 28941537

Citations 13

Authors

Mark W Hall

Kristin C Greathouse

Rajan K Thakkar

Eric A Sribnick

Jennifer A Muszynski

Affiliations

Soon will be listed here.

Abstract

Although many forms of critical illness are initiated by a proinflammatory stimulus, a compensatory anti-inflammatory response can occur with systemic inflammation. Immunoparalysis, an important form of acquired immunodeficiency, affects the innate and adaptive arms of the immune system. Immunoparalysis has been associated with increased risks for nosocomial infection and death in a variety of pediatric critical illnesses. Evidence suggests that immunoparalysis is reversible with immunostimulants. Highly standardized, prospective immune monitoring regimens are needed to better understand the immunologic effects of critical care treatment regimens and to enrich clinical trials with subjects most likely to benefit from immunostimulatory therapies.

Citing Articles

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