Clinicopathological Analysis in PTCL-NOS with CADM1 Expression

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2017 Sep 24

PMID 28940014

Citations 2

Authors

Takeharu Kato

Hiroaki Miyoshi

Seiichiro Kobayashi

Noriaki Yoshida

Yoshitaka Imaizumi

Masao Seto

Kaoru Uchimaru

Yasushi Miyazaki

Koichi Ohshima

Affiliations

Soon will be listed here.

Abstract

Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS), is a heterogeneous disease with respect to clinicopathological features. Cell adhesion molecule 1 (CADM1) has been reported to be ectopically expressed in adult T cell leukaemia/lymphoma (ATLL). However, the frequency of CADM1 expression remains unknown in peripheral T cell lymphomas. In the current study, CADM1 expression was analysed in 88 PTCL-NOS patients. CADM1 was expressed in 14 of 88 (15.9%) PTCL-NOS cases, and its expression was associated with C-C chemokine receptor type 4 (CCR4) expression and nuclear atypia. CADM1-positive PTCL-NOS cases (10/74) had a significantly poorer prognosis than CADM1-negative cases (64/74) (P = 0.001). Multivariate analysis confirmed that CADM1 expression was an independent prognostic factor in PTCL-NOS. These findings suggest that CADM1 expression is a novel prognostic factor for PTCL-NOS.

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