MicroRNA Expression Levels As Diagnostic Biomarkers for Intraductal Papillary Mucinous Neoplasm

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 24

PMID 28938594

Citations 10

Authors

Lei Wang

Jianming Zheng

Chang Sun

Li Wang

Gang Jin

Lei Xin

Zhendong Jin

Dong Wang

Zhaoshen Li

Affiliations

Soon will be listed here.

Abstract

Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies.

Citing Articles

MiR-223-3p in Cancer Development and Cancer Drug Resistance: Same Coin, Different Faces.

Barbagallo D, Ponti D, Bassani B, Bruno A, Pulze L, Akkihal S Int J Mol Sci. 2024; 25(15).

PMID: 39125761 PMC: 11311375. DOI: 10.3390/ijms25158191.

The Link between Diabetes, Pancreatic Tumors, and miRNAs-New Players for Diagnosis and Therapy?.

Kozlowska M, Sliwinska A Int J Mol Sci. 2023; 24(12).

PMID: 37373398 PMC: 10299694. DOI: 10.3390/ijms241210252.

Bioinformatic Analysis and Integration of Transcriptome and Proteome Results Identify Key Coding and Noncoding Genes Predicting Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Saha B, Chhatriya B, Pramanick S, Goswami S Biomed Res Int. 2021; 2021:1056622.

PMID: 34790815 PMC: 8592698. DOI: 10.1155/2021/1056622.

Application of EUS-based techniques in the evaluation of pancreatic cystic neoplasms.

Sun L, Huang H, Jin Z Endosc Ultrasound. 2021; 10(4):230-240.

PMID: 34213426 PMC: 8411565. DOI: 10.4103/EUS-D-20-00216.

PDS5A and PDS5B in Cohesin Function and Human Disease.

Zhang N, Coutinho L, Pati D Int J Mol Sci. 2021; 22(11).

PMID: 34070827 PMC: 8198109. DOI: 10.3390/ijms22115868.

References

Peng L, Hu Y, Chen D, Jiao S, Sun S . Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma. Oncotarget. 2016; 7(27):42007-42016. PMC: 5173112. DOI: 10.18632/oncotarget.9751. View

Peng L, Song Z, Chen D, LingHu R, Wang Y, Zhang X . GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer. Biomed Pharmacother. 2016; 84:1568-1574. DOI: 10.1016/j.biopha.2016.10.032. View

Gironella M, Seux M, Xie M, Cano C, Tomasini R, Gommeaux J . Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci U S A. 2007; 104(41):16170-5. PMC: 2042180. DOI: 10.1073/pnas.0703942104. View

Sohn T, Yeo C, Cameron J, Hruban R, Fukushima N, Campbell K . Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg. 2004; 239(6):788-97. PMC: 1356287. DOI: 10.1097/01.sla.0000128306.90650.aa. View

Chalret du Rieu M, Torrisani J, Selves J, Al Saati T, Souque A, Dufresne M . MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions. Clin Chem. 2010; 56(4):603-12. DOI: 10.1373/clinchem.2009.137364. View

Bloomston M, Frankel W, Petrocca F, Volinia S, Alder H, Hagan J . MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 2007; 297(17):1901-8. DOI: 10.1001/jama.297.17.1901. View

Nara S, Shimada K, Kosuge T, Kanai Y, Hiraoka N . Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. Am J Surg Pathol. 2008; 32(2):243-55. DOI: 10.1097/PAS.0b013e3181484f1e. View

Cheerla N, Gevaert O . MicroRNA based Pan-Cancer Diagnosis and Treatment Recommendation. BMC Bioinformatics. 2017; 18(1):32. PMC: 5237282. DOI: 10.1186/s12859-016-1421-y. View

Lin S, Gregory R . Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. PMC: 4615740. DOI: 10.1080/15476286.2015.1058478. View

10.

Habbe N, Koorstra J, Mendell J, Offerhaus G, Ryu J, Feldmann G . MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol Ther. 2008; 8(4):340-6. PMC: 2692997. DOI: 10.4161/cbt.8.4.7338. View

11.

Tang F, Hajkova P, Barton S, Lao K, Surani M . MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res. 2006; 34(2):e9. PMC: 1351374. DOI: 10.1093/nar/gnj009. View

12.

Lin S, Gregory R . MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015; 15(6):321-33. PMC: 4859809. DOI: 10.1038/nrc3932. View

13.

Liang Y, Zhu F, Zhang H, Chen D, Zhang X, Gao Q . Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model. Sci Rep. 2016; 6:29479. PMC: 4932495. DOI: 10.1038/srep29479. View

14.

Lubezky N, Loewenstein S, Ben-Haim M, Brazowski E, Marmor S, Pasmanik-Chor M . MicroRNA expression signatures in intraductal papillary mucinous neoplasm of the pancreas. Surgery. 2013; 153(5):663-72. DOI: 10.1016/j.surg.2012.11.016. View

15.

Davis-Dusenbery B, Hata A . MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways. Genes Cancer. 2011; 1(11):1100-14. PMC: 3083114. DOI: 10.1177/1947601910396213. View

16.

Fritz S, Hackert T, Hinz U, Hartwig W, Buchler M, Werner J . Role of serum carbohydrate antigen 19-9 and carcinoembryonic antigen in distinguishing between benign and invasive intraductal papillary mucinous neoplasm of the pancreas. Br J Surg. 2010; 98(1):104-10. DOI: 10.1002/bjs.7280. View

17.

Lee E, Gusev Y, Jiang J, Nuovo G, Lerner M, Frankel W . Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer. 2006; 120(5):1046-54. PMC: 2680248. DOI: 10.1002/ijc.22394. View

18.

Nara S, Onaya H, Hiraoka N, Shimada K, Sano T, Sakamoto Y . Preoperative evaluation of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas: clinical, radiological, and pathological analysis of 123 cases. Pancreas. 2008; 38(1):8-16. DOI: 10.1097/MPA.0b013e318181b90d. View

19.

Caponi S, Funel N, Frampton A, Mosca F, Santarpia L, Van der Velde A . The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms. Ann Oncol. 2012; 24(3):734-41. DOI: 10.1093/annonc/mds513. View

20.

Zhang Y, Wang Y, Yusufali A, Ashby F, Zhang D, Yin Z . Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. J Integr Med. 2014; 12(6):483-94. DOI: 10.1016/s2095-4964(14)60057-1. View