The Highly Expressed COL4A1 Genes Contributes to the Proliferation and Migration of the Invasive Ductal Carcinomas

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 24

PMID 28938546

Citations 27

Authors

Rongzhong Jin

Jia Shen

Tiancheng Zhang

Qiliang Liu

Caihua Liao

Hailin Ma

Sijing Li

Zhaoxia Yu

Affiliations

Soon will be listed here.

Abstract

Background: Invasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets.

Results: The total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enrichment analysis proved the most part of differentially expressed genes had connection with ECM-receptor interaction. The two genes lists were contrasted in PPI network, and miRNA regulation networks, The most two crucial genes were identified in our study, which may be helpful to improve Invasive ductal carcinoma treatment. Additionally, experimental results shows that the COL4A1 gene, one of identified genes, played important roles in both of proliferation and colony formation in Invasive ductal carcinoma.

Conclusions: Invasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell.

Citing Articles

Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets.

Sirek T, Krol-Jatrega K, Borawski P, Zmarzly N, Boron D, Ossowski P Front Oncol. 2025; 14():1515387.

PMID: 39850811 PMC: 11754234. DOI: 10.3389/fonc.2024.1515387.

From ductal carcinoma in situ to invasive breast cancer: the prognostic value of the extracellular microenvironment.

Hulahan T, Angel P J Exp Clin Cancer Res. 2024; 43(1):329.

PMID: 39716322 PMC: 11664872. DOI: 10.1186/s13046-024-03236-z.

Changes of collagen content in lung tissues of plateau yak and its mechanism of adaptation to hypoxia.

Li J, Huang N, Zhang X, Sun C, Chen J, Wei Q PeerJ. 2024; 12:e18250.

PMID: 39372716 PMC: 11451445. DOI: 10.7717/peerj.18250.

Comprehensive analysis of the expression, prognostic, and immune infiltration for COL4s in stomach adenocarcinoma.

Xu Y, Jin H, Chen Y, Yang Z, Xu D, Zhang X BMC Med Genomics. 2024; 17(1):168.

PMID: 38907304 PMC: 11191235. DOI: 10.1186/s12920-024-01934-3.

Unveiling Collagen's Role in Breast Cancer: Insights into Expression Patterns, Functions and Clinical Implications.

Li X, Jin Y, Xue J Int J Gen Med. 2024; 17:1773-1787.

PMID: 38711825 PMC: 11073151. DOI: 10.2147/IJGM.S463649.

References

Kimata K, Oike Y, Tani K, Shinomura T, Yamagata M, Uritani M . A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo. J Biol Chem. 1986; 261(29):13517-25. View

Kuhn K . Basement membrane (type IV) collagen. Matrix Biol. 1995; 14(6):439-45. DOI: 10.1016/0945-053x(95)90001-2. View

Arps D, Healy P, Zhao L, Kleer C, Pang J . Invasive ductal carcinoma with lobular features: a comparison study to invasive ductal and invasive lobular carcinomas of the breast. Breast Cancer Res Treat. 2013; 138(3):719-26. PMC: 3906642. DOI: 10.1007/s10549-013-2493-2. View

Gould D, Phalan F, Breedveld G, van Mil S, Smith R, Schimenti J . Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science. 2005; 308(5725):1167-71. DOI: 10.1126/science.1109418. View

Labelle-Dumais C, Dilworth D, Harrington E, de Leau M, Lyons D, Kabaeva Z . COL4A1 mutations cause ocular dysgenesis, neuronal localization defects, and myopathy in mice and Walker-Warburg syndrome in humans. PLoS Genet. 2011; 7(5):e1002062. PMC: 3098190. DOI: 10.1371/journal.pgen.1002062. View

Plaisier E, Gribouval O, Alamowitch S, Mougenot B, Prost C, Verpont M . COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N Engl J Med. 2007; 357(26):2687-95. DOI: 10.1056/NEJMoa071906. View

Xiong G, Deng L, Zhu J, Rychahou P, Xu R . Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014; 14:1. PMC: 3880410. DOI: 10.1186/1471-2407-14-1. View

Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould D, Sun Y . Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016; 14:59. PMC: 4942891. DOI: 10.1186/s12915-016-0281-2. View

Turashvili G, Bouchal J, Baumforth K, Wei W, Dziechciarkova M, Ehrmann J . Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer. 2007; 7:55. PMC: 1852112. DOI: 10.1186/1471-2407-7-55. View

10.

Diboun I, Wernisch L, Orengo C, Koltzenburg M . Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 2006; 7:252. PMC: 1618401. DOI: 10.1186/1471-2164-7-252. View

11.

Shannon P, Markiel A, Ozier O, Baliga N, Wang J, Ramage D . Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003; 13(11):2498-504. PMC: 403769. DOI: 10.1101/gr.1239303. View

12.

Carrera P, Di Resta C, Volonteri C, Castiglioni E, Bonfiglio S, Lazarevic D . Exome sequencing and pathway analysis for identification of genetic variability relevant for bronchopulmonary dysplasia (BPD) in preterm newborns: A pilot study. Clin Chim Acta. 2015; 451(Pt A):39-45. DOI: 10.1016/j.cca.2015.01.001. View

13.

Salem O, Erdem N, Jung J, Munstermann E, Worner A, Wilhelm H . The highly expressed 5'isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration. BMC Genomics. 2016; 17:566. PMC: 4977694. DOI: 10.1186/s12864-016-2869-x. View

14.

Toikkanen S, Pylkkanen L, Joensuu H . Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma. Br J Cancer. 1997; 76(9):1234-40. PMC: 2228126. DOI: 10.1038/bjc.1997.540. View

15.

J van t Veer L, Dai H, van de Vijver M, He Y, Hart A, Bernards R . Expression profiling predicts outcome in breast cancer. Breast Cancer Res. 2003; 5(1):57-8. PMC: 154139. DOI: 10.1186/bcr562. View

16.

Haniel A, Welge-Lussen U, Kuhn K, Poschl E . Identification and characterization of a novel transcriptional silencer in the human collagen type IV gene COL4A2. J Biol Chem. 1995; 270(19):11209-15. DOI: 10.1074/jbc.270.19.11209. View

17.

Mersin H, Yildirim E, Gulben K, BerberoGlu U . Is invasive lobular carcinoma different from invasive ductal carcinoma?. Eur J Surg Oncol. 2003; 29(4):390-5. DOI: 10.1053/ejso.2002.1423. View

18.

Cong D, He M, Chen S, Liu X, Liu X, Sun H . Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas. Onco Targets Ther. 2015; 8:2271-7. PMC: 4556042. DOI: 10.2147/OTT.S85753. View

19.

Dennis Jr G, Sherman B, Hosack D, Yang J, Gao W, Lane H . DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003; 4(5):P3. View

20.

Kuang J, Zhao M, Li H, Dang W, Li W . Identification of potential therapeutic target genes and mechanisms in head and neck squamous cell carcinoma by bioinformatics analysis. Oncol Lett. 2016; 11(5):3009-3014. PMC: 4840659. DOI: 10.3892/ol.2016.4358. View