MiR-23a Targets RUNX2 and Suppresses Ginsenoside Rg1-induced Angiogenesis in Endothelial Cells

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 24

PMID 28938538

Citations 7

Authors

Xiao-Dong Wu

Ting Guo

Li Liu

Chao Wang

Kun Zhang

Han-Qiang Liu

Feng Wang

Wen-Dong Bai

Meng-Yao Zhang

Affiliations

Soon will be listed here.

Abstract

Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 also induces the expression of proangiogenic factors, such as vascular endothelial growth factor (VEGF-A), in endothelial cells. Unfortunately, angiogenesis positively correlates with cancer development. In this study, we identified RUNX2 as a regulator of ginsenoside Rg1-induced angiogenesis for the first time. We found that RUNX2 was directly targeted and regulated by miR-23a. Additionally, miR-23a was shown to inhibit angiogenesis in both human umbilical vein endothelial cells (HUVECs) and in zebrafish. Furthermore, a decrease in RUNX2 expression resulted in translational repression of VEGF-A in HUVECs. Taken together, this study identified a MiR-23a/RUNX2/VEGF-A pathway in angiogenesis and shed light on the molecular mechanism of Rg1-induced angiogenesis. Thus, RUNX2 might be a potential therapeutic target in Rg1-mediated angiogenesis in cancer.

Citing Articles

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