Significant Prognostic Factors Affecting Treatment Outcomes of Salivary Gland Carcinoma: a Multicenter Retrospective Analysis

Overview

Journal Odontology

Specialty Dentistry

Date 2017 Sep 23

PMID 28936637

Citations 4

Authors

Shin-Ichi Yamada

Hiroshi Kurita

Takahiro Kamata

Tadaaki Kirita

Michihiro Ueda

Tetsuro Yamashita

Yoshihide Ota

Mitsunobu Otsuru

Nobuhiro Yamakawa

Masaya Okura

Tomonao Aikawa

Masahiro Umeda

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the prognostic factor in salivary gland carcinoma patients. Clinical and pathological data of 211 consecutive patients who treated with curative intent were analyzed. The overall survival (OS) rate, local control rate, and distant metastasis rate were calculated. To examine a prognostic factor in salivary gland carcinoma patients, a multivariate analysis was performed. The 5-year-OS rate was 84.0%, and 10-year was 69.2%. The 5-year-local control rate was 84.6%, and 10-year was 70.1%. The 5-year-distant metastasis rate was 16.9%, and 10-year was 21.1%. In a multivariate analysis, the OS rate was affected by pN(+), high-grade malignancy, and primary tumor size. The local control was affected by the primary tumor size, high-grade malignancy, and the status of the surgical margin. The primary tumor size and pN(+) were associated with the distant metastasis. The results of this study suggested that pN(+), malignancy grade, primary tumor size, and the margin status might affect the prognosis of salivary gland carcinoma patients. Postoperative radiotherapy and adjuvant chemotherapy were suggested the possibility of contribution to the good prognosis of salivary gland carcinoma patients.

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